@article{bb9257d3786e422aa305d399036d2d5d,
title = "Cardiac Remodeling After Myocardial Infarction: Functional Contribution of microRNAs to Inflammation and Fibrosis",
abstract = "After an ischemic injury, the heart undergoes a complex process of structural and functional remodeling that involves several steps, including inflammatory and fibrotic responses. In this review, we are focusing on the contribution of microRNAs in the regulation of inflammation and fibrosis after myocardial infarction. We summarize the most updated studies exploring the interactions between microRNAs and key regulators of inflammation and fibroblast activation and we discuss the recent discoveries, including clinical applications, in these rapidly advancing fields.",
keywords = "cardiac remodeling, clinical trials, drug development, epigenetics, heart failure, ischemic heart disease, non-coding RNA, oxidative stress",
author = "Fahimeh Varzideh and Urna Kansakar and Kwame Donkor and Scott Wilson and Jankauskas, {Stanislovas S.} and Pasquale Mone and Xujun Wang and Angela Lombardi and Gaetano Santulli",
note = "Funding Information: The Santulli{\textquoteright}s Lab was supported in part by the National Institutes of Health (R01-HL146691, R01-DK123259, NIH: R01-HL159062, R01-DK033823, T32-HL144456, and R56-AG066431 to GS), the Diabetes Action Research and Education Foundation (to GS), and the Irma T. Hirschl and Monique Weill-Caulier Trusts (to GS). SW was supported by a Glorney-Raisbeck grant. FV and SSJ hold postdoctoral fellowships from the American Heart Association (AHA-22POST915561 and AHA-21POST836407, respectively). Publisher Copyright: Copyright {\textcopyright} 2022 Varzideh, Kansakar, Donkor, Wilson, Jankauskas, Mone, Wang, Lombardi and Santulli.",
year = "2022",
month = apr,
day = "13",
doi = "10.3389/fcvm.2022.863238",
language = "English (US)",
volume = "9",
journal = "Frontiers in Cardiovascular Medicine",
issn = "2297-055X",
publisher = "Frontiers Media S. A.",
}