Carcinosarcoma of bladder following long-term cyclophosphamide therapy

S. H. Sigal, J. E. Tomaszewski, J. J. Brooks, A. Wein, V. A. LiVolsi

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Since the advent of long-term cyclophosphamide therapy, an association between this agent and the subsequent development of bladder neoplasms has been documented. Only six sarcomas have been reported, to our knowledge. This report describes the first case in which a leiomyosarcoma and an invasive transitional cell carcinoma (ie, carcinosarcoma) developed in a patient with non-Hodgkin's lymphoma treated with 240 g of cyclophosphamide over a 6.5-year period.

Original languageEnglish (US)
Pages (from-to)1049-1051
Number of pages3
JournalArchives of Pathology and Laboratory Medicine
Issue number10
StatePublished - Jan 1 1991
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology


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