Carbamazepine-induced constipation

Alan B. Ettinger; Shlomo Shinnar; Mark J. Sinnett; Solomon L. Moshé

doi:10.1016/S0896-6974(05)80140-9

Carbamazepine-induced constipation

Alan B. Ettinger, Shlomo Shinnar, Mark J. Sinnett, Solomon L. Moshé

Neurology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

We report three patients who developed constipation as an adverse effect of carbamazepine (CBZ) therapy. Constipation occurred within a few days of CBZ introduction, resolved after CBZ discontinuation, and was not dose-responsive. It was refractory to the concomitant use of oral laxatives in two cases, necessitating CBZ discontinuation. In a third patient, constipation was controlled by a fiber agent, allowing continuation of CBZ therapy. Potential mechanisms for this idiosyncratic, poorly reported adverse event are discussed.

Original language	English (US)
Pages (from-to)	191-193
Number of pages	3
Journal	Journal of Epilepsy
Volume	5
Issue number	3
DOIs	https://doi.org/10.1016/S0896-6974(05)80140-9
State	Published - 1992

Keywords

Carbamazepine
Constipation
Gastrointestinal disorder

ASJC Scopus subject areas

General Neuroscience
Clinical Neurology

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10.1016/S0896-6974(05)80140-9

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title = "Carbamazepine-induced constipation",

abstract = "We report three patients who developed constipation as an adverse effect of carbamazepine (CBZ) therapy. Constipation occurred within a few days of CBZ introduction, resolved after CBZ discontinuation, and was not dose-responsive. It was refractory to the concomitant use of oral laxatives in two cases, necessitating CBZ discontinuation. In a third patient, constipation was controlled by a fiber agent, allowing continuation of CBZ therapy. Potential mechanisms for this idiosyncratic, poorly reported adverse event are discussed.",

keywords = "Carbamazepine, Constipation, Gastrointestinal disorder",

author = "Ettinger, {Alan B.} and Shlomo Shinnar and Sinnett, {Mark J.} and Mosh{\'e}, {Solomon L.}",

year = "1992",

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language = "English (US)",

volume = "5",

pages = "191--193",

journal = "Journal of Epilepsy",

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T1 - Carbamazepine-induced constipation

AU - Ettinger, Alan B.

AU - Shinnar, Shlomo

AU - Sinnett, Mark J.

AU - Moshé, Solomon L.

PY - 1992

Y1 - 1992

N2 - We report three patients who developed constipation as an adverse effect of carbamazepine (CBZ) therapy. Constipation occurred within a few days of CBZ introduction, resolved after CBZ discontinuation, and was not dose-responsive. It was refractory to the concomitant use of oral laxatives in two cases, necessitating CBZ discontinuation. In a third patient, constipation was controlled by a fiber agent, allowing continuation of CBZ therapy. Potential mechanisms for this idiosyncratic, poorly reported adverse event are discussed.

AB - We report three patients who developed constipation as an adverse effect of carbamazepine (CBZ) therapy. Constipation occurred within a few days of CBZ introduction, resolved after CBZ discontinuation, and was not dose-responsive. It was refractory to the concomitant use of oral laxatives in two cases, necessitating CBZ discontinuation. In a third patient, constipation was controlled by a fiber agent, allowing continuation of CBZ therapy. Potential mechanisms for this idiosyncratic, poorly reported adverse event are discussed.

KW - Carbamazepine

KW - Constipation

KW - Gastrointestinal disorder

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SP - 191

EP - 193

JO - Journal of Epilepsy

JF - Journal of Epilepsy

IS - 3

ER -

Carbamazepine-induced constipation

Abstract

Keywords

ASJC Scopus subject areas

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