TY - JOUR
T1 - Can ends justify the means? Digging deep for human fusion genes of prokaryotic origin.
AU - Yiting, Y.
AU - Chaturvedi, Iti
AU - Meow, Liew Kim
AU - Kangueane, Pandjassarame
AU - Sakharkar, Meena Kishore
PY - 2004/9/1
Y1 - 2004/9/1
N2 - Gene fusion has been described as an important evolutionary phenomenon. This report focuses on identifying, analyzing, and tabulating human fusion proteins of prokaryotic origin. These fusion proteins are found to mimic operons, simulate protein-protein interfaces in prokaryotes, exhibiting multiple functions and alternative splicing in humans. The accredited biological functions for each of these proteins is made available as a database at http://sege.ntu.edu.sg/wester/fusion/
AB - Gene fusion has been described as an important evolutionary phenomenon. This report focuses on identifying, analyzing, and tabulating human fusion proteins of prokaryotic origin. These fusion proteins are found to mimic operons, simulate protein-protein interfaces in prokaryotes, exhibiting multiple functions and alternative splicing in humans. The accredited biological functions for each of these proteins is made available as a database at http://sege.ntu.edu.sg/wester/fusion/
UR - http://www.scopus.com/inward/record.url?scp=33749105321&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33749105321&partnerID=8YFLogxK
U2 - 10.2741/1451
DO - 10.2741/1451
M3 - Article
C2 - 15353329
AN - SCOPUS:33749105321
SN - 1093-9946
VL - 9
SP - 2964
EP - 2971
JO - Frontiers in bioscience : a journal and virtual library
JF - Frontiers in bioscience : a journal and virtual library
ER -