Cambios en biomarcadores del estrés oxidativo inducidos por la pubertad

Translated title of the contribution: Changes in oxidative stress biomarkers induced by puberty

J. L. Pérez-Navero, J. D. Benítez-Sillero, M. Gil-Campos, M. Guillén-Del Castillo, I. Tasset, I. Túnez

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Aim: Evaluate the influence of puberty in oxidative stress. Subjects and methods: The study included 38 prepubescent males with Tanner G1-P1 and 32 healthy pubescent boys with Tanner G3-4-P3-4. Weight, height and body mass index, heart rate, blood pressure values were with in the 50 percentile 50±1SD for their age. The biomarkers were measured in saliva, as a good correlation between saliva and plasma levels has been reported in lipoperoxidation products, reduced glutathione and catalase. Results: Pubescent boys had significantly higher levels of lipoperoxidation products (P<0.001) compared with the prepubertal group, with no significant differences in the other parameters measured. There was a significant positive correlation between lipoperoxides and reduced glutathione in these children. Conclusion: It is the first time that an increase of lipoperoxidation products has been reported inpubertal boys and this biomarker could playarole in the development of oxidative stress in this stage of life.

Translated title of the contributionChanges in oxidative stress biomarkers induced by puberty
Original languageSpanish
Pages (from-to)424-428
Number of pages5
JournalAnales de Pediatria
Issue number5
StatePublished - May 2009
Externally publishedYes


  • Catalase
  • Lipoperoxidation products
  • Oxidative stress
  • Puberty
  • Reduced glutathione

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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