Buprenorphine administration during gestation induces hepatotoxicity in the rat fetus

Farshid Fayaz; Asghar Zarban; Michael Aschner; Hamed Aramjoo; Babak Roshanravan; Mohsen Foadodini; Amir Abderam; Saeed Samarghandian; Tahereh Farkhondeh

doi:10.1139/cjpp-2022-0113

Buprenorphine administration during gestation induces hepatotoxicity in the rat fetus

Farshid Fayaz, Asghar Zarban, Michael Aschner, Hamed Aramjoo, Babak Roshanravan, Mohsen Foadodini, Amir Abderam, Saeed Samarghandian, Tahereh Farkhondeh

Molecular Pharmacology

Research output: Contribution to journal › Article › peer-review

Abstract

This study investigated the effect of buprenorphine (BUP) on the livers of pups exposed to this drug during the fetal stage. BUP decreased the activities of serum liver enzymes in exposed animals versus the controls. BUP (0.5 mg/kg) decreased malon-dialdehyde levels and increased the glutathione levels in the liver of animals versus other groups. The superoxide dismutase activity was elevated in the BUP 0.5 mg/kg group versus the control group. BUP (1 mg/kg) induced histopathological changes in the livers of pups. In conclusion, BUP may induce hepatotoxicity in pups exposed to this drug during the fetal stage.

Original language	English (US)
Pages (from-to)	74-79
Number of pages	6
Journal	Canadian Journal of Physiology and Pharmacology
Volume	101
Issue number	2
DOIs	https://doi.org/10.1139/cjpp-2022-0113
State	Published - Feb 2023

Keywords

buprenorphine
gestation
liver
oxidative stress parameters
pup
rat

ASJC Scopus subject areas

Physiology
Pharmacology
Physiology (medical)

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10.1139/cjpp-2022-0113

Cite this

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title = "Buprenorphine administration during gestation induces hepatotoxicity in the rat fetus",

abstract = "This study investigated the effect of buprenorphine (BUP) on the livers of pups exposed to this drug during the fetal stage. BUP decreased the activities of serum liver enzymes in exposed animals versus the controls. BUP (0.5 mg/kg) decreased malon-dialdehyde levels and increased the glutathione levels in the liver of animals versus other groups. The superoxide dismutase activity was elevated in the BUP 0.5 mg/kg group versus the control group. BUP (1 mg/kg) induced histopathological changes in the livers of pups. In conclusion, BUP may induce hepatotoxicity in pups exposed to this drug during the fetal stage.",

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AU - Fayaz, Farshid

AU - Zarban, Asghar

AU - Aschner, Michael

AU - Aramjoo, Hamed

AU - Roshanravan, Babak

AU - Foadodini, Mohsen

AU - Abderam, Amir

AU - Samarghandian, Saeed

AU - Farkhondeh, Tahereh

PY - 2023/2

Y1 - 2023/2

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AB - This study investigated the effect of buprenorphine (BUP) on the livers of pups exposed to this drug during the fetal stage. BUP decreased the activities of serum liver enzymes in exposed animals versus the controls. BUP (0.5 mg/kg) decreased malon-dialdehyde levels and increased the glutathione levels in the liver of animals versus other groups. The superoxide dismutase activity was elevated in the BUP 0.5 mg/kg group versus the control group. BUP (1 mg/kg) induced histopathological changes in the livers of pups. In conclusion, BUP may induce hepatotoxicity in pups exposed to this drug during the fetal stage.

KW - buprenorphine

KW - gestation

KW - liver

KW - oxidative stress parameters

KW - pup

KW - rat

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Buprenorphine administration during gestation induces hepatotoxicity in the rat fetus

Abstract

Keywords

ASJC Scopus subject areas

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