Bordetella pertussis does not induce β-adrenergic blockade

E. Hewlett, A. Spiegel, J. Wolff, G. Aurbach, C. R. Manclark

Research output: Contribution to journalArticlepeer-review


Bordetella pertussis organisms induce histamine sensitivity and diminish the normal hyperglycemic response to epinephrine in experimental animals. These effects have been attributed to β-adrenergic blockade. However, under conditions in which the decrease in epinephrine-induced hyperglycemia after B. pertussis administration was demonstrable, there was no change in rat reticulocyte β-adrenergic receptor number or affinity measured by iodohydroxybenzylpindolol binding or in isoproterenol-stimulated adenylate cyclase activity. Therefore, there was no generalized β-adrenergic blockade induced by B. pertussis. The observed effects can be explained by the hypersecretion of insulin resulting from B. pertussis administration.

Original languageEnglish (US)
Pages (from-to)430-434
Number of pages5
JournalUnknown Journal
Issue number2
StatePublished - 1978
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases


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