@article{0d88f9fc78fc493bba982dc8d242e689,
title = "Bone morphogenetic proteins promote astroglial lineage commitment by mammalian subventricular zone progenitor cells",
abstract = "The epigenetic signals that regulate lineage development in the embryonic mammalian brain are poorly understood. Here we demonstrate that a specific subclass of the transforming growth factor β superfamily, the bone morphogenetic proteins (BMPs), cause the selective, dose-dependent elaboration of the astroglial lineage from murine embryonic subventricular zone (SVZ) multipotent progenitor cells. The astroglial inductive effect is characterized by enhanced morphological complexity and expression of glial fibrillary acidic protein, with concurrent suppression of neuronal and oligodendroglial cell fates. SVZ progenitor cells express transcripts for the appropriate BMP-specific type I and II receptor subunits and selective BMP ligands, suggesting the presence of paracrine or autocrine developmental signaling pathways (or both). These observations suggest that the BMPs have a selective role in determining the cell fate of SVZ multipotent progenitor cells or their more developmentally restricted progeny.",
author = "Gross, {Robert E.} and Mehler, {Mark F.} and Mabie, {Peter C.} and Ziying Zang and Linda Santschi and Kessler, {John A.}",
note = "Funding Information: Correspondence should be addressed to M. F. M. The authors wish to thank Tam Ngo for excellent technical assistance and the following individuals for their generous supply of the reagents used in this study: BMP2, BMP4, BMP5, and BMP6 and murine BMP cDNA probes, Anthony Celeste, John Wozney, and the Genetics Institute; OP1 and neutralizing antibody, Marc Charette and Creative Biomolecules; activin A, Genentech; TuJ1, Anthony Frankfurter (University of Virginia); O4, Ranscht, and galC antibodies, Steve Pfeiffer (University of Connecticut); NF66, Alex Chiu (Albert Einstein College of Medicine); Y b –GST and MAP2, Wendy Cammer (Albert Einstein College of Medicine). This work was supported by the Muscular Dystrophy Association, an Irma T. Hirschl Career Scientist Award (M. F. M.), and United States Public Health Service grants NS-20013, NS-20778, and NS-34758 (J. A. K.). ",
year = "1996",
month = oct,
doi = "10.1016/S0896-6273(00)80193-2",
language = "English (US)",
volume = "17",
pages = "595--606",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "4",
}