Biphenotypic leukemia with unusual chromosomal translocation in a patient treated for melanoma

Elisabeth Paietta, Peter Papenhausen, Niculae Ciobanu, Janice P. Dutcher, Peter H. Wiernik

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


A patient in complete remission from malignant melanoma but with refractory anemia after nitrosourea treatment developed acute biphenotypic leukemia. This disease, progression was accompanied by expansion of a cytogenetically abnormal clone. At first cytogenetic analysis, 1 year post discontinuation of chemotherapy, only 25% of the metaphases examined were hydodiploid with monosomy 7. Six months later, all of the metaphase seen were 45,XY, -7. Six months before overt acute leukemia was diagnosed, an additional chromosome abnormality emerged, t(2;3)(q31;q27). Although the translocation was present in all metaphases examined, the patient progressed into an acute leukemia with two components: one TdT-positive, Ia-positive, and the other TdT-negative, Ia-positive, monocytoid antigen-positive. This mixed leukemia was identified by double fluorescence staining for intranuclear TdT and surface labeling with a monocyte-specific monoclonal antibody.

Original languageEnglish (US)
Pages (from-to)355-360
Number of pages6
JournalCancer Genetics and Cytogenetics
Issue number4
StatePublished - Apr 15 1986

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research


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