TY - JOUR
T1 - Biphenotypic leukemia with unusual chromosomal translocation in a patient treated for melanoma
AU - Paietta, Elisabeth
AU - Papenhausen, Peter
AU - Ciobanu, Niculae
AU - Dutcher, Janice P.
AU - Wiernik, Peter H.
PY - 1986/4/15
Y1 - 1986/4/15
N2 - A patient in complete remission from malignant melanoma but with refractory anemia after nitrosourea treatment developed acute biphenotypic leukemia. This disease, progression was accompanied by expansion of a cytogenetically abnormal clone. At first cytogenetic analysis, 1 year post discontinuation of chemotherapy, only 25% of the metaphases examined were hydodiploid with monosomy 7. Six months later, all of the metaphase seen were 45,XY, -7. Six months before overt acute leukemia was diagnosed, an additional chromosome abnormality emerged, t(2;3)(q31;q27). Although the translocation was present in all metaphases examined, the patient progressed into an acute leukemia with two components: one TdT-positive, Ia-positive, and the other TdT-negative, Ia-positive, monocytoid antigen-positive. This mixed leukemia was identified by double fluorescence staining for intranuclear TdT and surface labeling with a monocyte-specific monoclonal antibody.
AB - A patient in complete remission from malignant melanoma but with refractory anemia after nitrosourea treatment developed acute biphenotypic leukemia. This disease, progression was accompanied by expansion of a cytogenetically abnormal clone. At first cytogenetic analysis, 1 year post discontinuation of chemotherapy, only 25% of the metaphases examined were hydodiploid with monosomy 7. Six months later, all of the metaphase seen were 45,XY, -7. Six months before overt acute leukemia was diagnosed, an additional chromosome abnormality emerged, t(2;3)(q31;q27). Although the translocation was present in all metaphases examined, the patient progressed into an acute leukemia with two components: one TdT-positive, Ia-positive, and the other TdT-negative, Ia-positive, monocytoid antigen-positive. This mixed leukemia was identified by double fluorescence staining for intranuclear TdT and surface labeling with a monocyte-specific monoclonal antibody.
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U2 - 10.1016/0165-4608(86)90217-7
DO - 10.1016/0165-4608(86)90217-7
M3 - Article
C2 - 2937529
AN - SCOPUS:0022586817
SN - 0165-4608
VL - 21
SP - 355
EP - 360
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 4
ER -