Biological variability of lipoproteins and apolipoproteins in patients referred to a lipid clinic

Stephanie D. Kafonek, Carol A. Derby, Paul S. Bachorik

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


We determined the physiological variability of total cholesterol, high- (HDL) and low-density lipoprotein (LDL) cholesterol, triglycerides, and apolipoproteins A-l and B in fasting blood samples from patients referred to the Johns Hopkins Lipid Referral Clinic. Samples were taken on each of three occasions during baseline evaluation visits before the patients were treated. The median physiological coefficients of variation (CVP) were as follows: total cholesterol, 5.0%; triglycerides, 17.8%; HDL cholesterol, 7.1%; LDL cholesterol, calculated from the previous three measurements, 7.8%; and apolipoproteins A-l and B, 7.1% and 6.4%, respectively. There were no significant differences in CVp between children (≤18 years) and adults (>18 years) for any of the measurements. On the basis of our findings, single measurements in serial samples taken on three occasions suffice to establish the patients' usual values with the following precisions (± 1 CV): total cholesterol, ± 4%; triglycerides, ± 11%; HDL cholesterol, ± 8%; LDL cholesterol, ± 6%; and apolipo-proteins A-l and B, ± 7%.

Original languageEnglish (US)
Pages (from-to)864-872
Number of pages9
JournalClinical chemistry
Issue number6
StatePublished - 1992
Externally publishedYes


  • Baseline values
  • Cholesterol
  • Intra-individual variation
  • Screening

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical


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