Abstract
Objectives: This second segment of the two-part review summarises several modern high-throughput methods in genomics, epigenetics and molecular biology. Many principles from nucleotide sequencing and transcriptomics can be applied to other high-throughput molecular biology techniques. Specifically, this manuscript reviews: array comparative genome hybridisation; single nucleotide polymorphism arrays; microarray technology, used to study epigenetics; and methodology applied in proteomics. Finally, the review describes current methods for the integration of multiple molecular biology platforms. Conclusion: Progress in treating human disease in general will require close collaboration with experts in bioinformatics. Improved understanding, by clinicians and physician-scientists in our field, of the concepts presented in both parts of this review will advance diagnosis and therapy for diseases of the head and neck.
Original language | English (US) |
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Pages (from-to) | 942-947 |
Number of pages | 6 |
Journal | Journal of Laryngology and Otology |
Volume | 128 |
Issue number | 11 |
DOIs | |
State | Published - Nov 20 2014 |
Keywords
- Bioinformatics
- Comparative Genomic Hybridization
- DNA Methylation
- Epigenomics
- Otolaryngology
- Polymorphism
- Proteomics
- Single Nucleotide
ASJC Scopus subject areas
- Otorhinolaryngology