Bioinformatics analysis: Gene fusion

Meena Kishore Sakharkar; Yiting Yu; Pandjassarame Kangueane

doi:10.1007/978-0-387-84870-9_14

Bioinformatics analysis: Gene fusion

Meena Kishore Sakharkar, Yiting Yu, Pandjassarame Kangueane

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Gene fusion is an important evolutionary phenomenon. Human fusion proteins consisting of two or more fusion partners of bacterial origin exhibit accreted (enhanced or novel) function. These proteins mimic operons, simulate protein subunit interfaces in bacteria, exhibit multiple functions, and show alternative splicing in humans. They are also associated with metabolites having greater connectivity in complex networks.

Original language	English (US)
Title of host publication	Bioinformatics
Subtitle of host publication	A Concept-Based Introduction
Publisher	Springer US
Pages	175-181
Number of pages	7
ISBN (Print)	9783540241669
DOIs	https://doi.org/10.1007/978-0-387-84870-9_14
State	Published - 2007
Externally published	Yes

Keywords

Domain
Evolution
Fusion protein
Gene fusion

ASJC Scopus subject areas

General Computer Science

Access to Document

10.1007/978-0-387-84870-9_14

Cite this

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title = "Bioinformatics analysis: Gene fusion",

abstract = "Gene fusion is an important evolutionary phenomenon. Human fusion proteins consisting of two or more fusion partners of bacterial origin exhibit accreted (enhanced or novel) function. These proteins mimic operons, simulate protein subunit interfaces in bacteria, exhibit multiple functions, and show alternative splicing in humans. They are also associated with metabolites having greater connectivity in complex networks.",

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author = "Sakharkar, {Meena Kishore} and Yiting Yu and Pandjassarame Kangueane",

year = "2007",

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AU - Yu, Yiting

AU - Kangueane, Pandjassarame

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AB - Gene fusion is an important evolutionary phenomenon. Human fusion proteins consisting of two or more fusion partners of bacterial origin exhibit accreted (enhanced or novel) function. These proteins mimic operons, simulate protein subunit interfaces in bacteria, exhibit multiple functions, and show alternative splicing in humans. They are also associated with metabolites having greater connectivity in complex networks.

KW - Domain

KW - Evolution

KW - Fusion protein

KW - Gene fusion

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ER -

Bioinformatics analysis: Gene fusion

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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