Bioinformatics analysis: Gene fusion

Meena Kishore Sakharkar; Yiting Yu; Pandjassarame Kangueane

doi:10.1007/978-0-387-84870-9_14

Bioinformatics analysis: Gene fusion

Meena Kishore Sakharkar, Yiting Yu, Pandjassarame Kangueane

Epidemiology & Population Health

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Gene fusion is an important evolutionary phenomenon. Human fusion proteins consisting of two or more fusion partners of bacterial origin exhibit accreted (enhanced or novel) function. These proteins mimic operons, simulate protein subunit interfaces in bacteria, exhibit multiple functions, and show alternative splicing in humans. They are also associated with metabolites having greater connectivity in complex networks.

Original language	English (US)
Title of host publication	Bioinformatics
Subtitle of host publication	A Concept-Based Introduction
Publisher	Springer US
Pages	175-181
Number of pages	7
ISBN (Print)	9783540241669
DOIs	https://doi.org/10.1007/978-0-387-84870-9_14
State	Published - Dec 1 2007

Keywords

Domain
Evolution
Fusion protein
Gene fusion

ASJC Scopus subject areas

Computer Science(all)

Access to Document

10.1007/978-0-387-84870-9_14

Cite this

@inbook{ca1e51d8b15b4a5da32dc71f1061ddcd,

title = "Bioinformatics analysis: Gene fusion",

abstract = "Gene fusion is an important evolutionary phenomenon. Human fusion proteins consisting of two or more fusion partners of bacterial origin exhibit accreted (enhanced or novel) function. These proteins mimic operons, simulate protein subunit interfaces in bacteria, exhibit multiple functions, and show alternative splicing in humans. They are also associated with metabolites having greater connectivity in complex networks.",

keywords = "Domain, Evolution, Fusion protein, Gene fusion",

author = "Sakharkar, {Meena Kishore} and Yiting Yu and Pandjassarame Kangueane",

year = "2007",

month = dec,

day = "1",

doi = "10.1007/978-0-387-84870-9_14",

language = "English (US)",

isbn = "9783540241669",

pages = "175--181",

booktitle = "Bioinformatics",

publisher = "Springer US",

}

TY - CHAP

T1 - Bioinformatics analysis

T2 - Gene fusion

AU - Sakharkar, Meena Kishore

AU - Yu, Yiting

AU - Kangueane, Pandjassarame

PY - 2007/12/1

Y1 - 2007/12/1

N2 - Gene fusion is an important evolutionary phenomenon. Human fusion proteins consisting of two or more fusion partners of bacterial origin exhibit accreted (enhanced or novel) function. These proteins mimic operons, simulate protein subunit interfaces in bacteria, exhibit multiple functions, and show alternative splicing in humans. They are also associated with metabolites having greater connectivity in complex networks.

AB - Gene fusion is an important evolutionary phenomenon. Human fusion proteins consisting of two or more fusion partners of bacterial origin exhibit accreted (enhanced or novel) function. These proteins mimic operons, simulate protein subunit interfaces in bacteria, exhibit multiple functions, and show alternative splicing in humans. They are also associated with metabolites having greater connectivity in complex networks.

KW - Domain

KW - Evolution

KW - Fusion protein

KW - Gene fusion

UR - http://www.scopus.com/inward/record.url?scp=84900924804&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84900924804&partnerID=8YFLogxK

U2 - 10.1007/978-0-387-84870-9_14

DO - 10.1007/978-0-387-84870-9_14

M3 - Chapter

AN - SCOPUS:84900924804

SN - 9783540241669

SP - 175

EP - 181

BT - Bioinformatics

PB - Springer US

ER -

Bioinformatics analysis: Gene fusion

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this