Beta-hemolytic group a streptococcal orthopaedic infections: Our institutional experience and review of the literature

Priya Nori; Naiha Nadeem; Nidhi Saraiya; Wendy Szymczak; Carmel Boland-Reardon; Mani Kahn

doi:10.1016/j.jor.2020.03.015

Beta-hemolytic group a streptococcal orthopaedic infections: Our institutional experience and review of the literature

Priya Nori, Naiha Nadeem, Nidhi Saraiya, Wendy Szymczak, Carmel Boland-Reardon, Mani Kahn

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Group A streptococcal (GAS) infections have high morbidity and mortality due to toxin production and tissue invasion. We reviewed all orthopaedic GAS infections at our medical centre between January 2017 and April 2019. Median age was 56 years. At least 60% had a body mass index (BMI) of ≥30 kg/m². Median Charlson comorbidity score was 3 (range 0–7). Clinical cure at 90 days was achieved in only 62%. All 4 patients with underlying orthopaedic hardware were cured. Toxin-neutralizing antibiotics and intravenous immunoglobulin were underutilized. Our review confirms poor outcomes from GAS orthopaedic infections without optimal management.

Original language	English (US)
Pages (from-to)	150-154
Number of pages	5
Journal	Journal of Orthopaedics
Volume	21
DOIs	https://doi.org/10.1016/j.jor.2020.03.015
State	Published - Sep 1 2020

Keywords

Group A streptococci (GAS)
Hardware infection
Necrotizing fasciitis
Osteomyelitis
Streptococcus pyogenes

ASJC Scopus subject areas

Orthopedics and Sports Medicine

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10.1016/j.jor.2020.03.015

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title = "Beta-hemolytic group a streptococcal orthopaedic infections: Our institutional experience and review of the literature",

abstract = "Group A streptococcal (GAS) infections have high morbidity and mortality due to toxin production and tissue invasion. We reviewed all orthopaedic GAS infections at our medical centre between January 2017 and April 2019. Median age was 56 years. At least 60% had a body mass index (BMI) of ≥30 kg/m2. Median Charlson comorbidity score was 3 (range 0–7). Clinical cure at 90 days was achieved in only 62%. All 4 patients with underlying orthopaedic hardware were cured. Toxin-neutralizing antibiotics and intravenous immunoglobulin were underutilized. Our review confirms poor outcomes from GAS orthopaedic infections without optimal management.",

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AU - Nadeem, Naiha

AU - Saraiya, Nidhi

AU - Szymczak, Wendy

AU - Boland-Reardon, Carmel

AU - Kahn, Mani

PY - 2020/9/1

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AB - Group A streptococcal (GAS) infections have high morbidity and mortality due to toxin production and tissue invasion. We reviewed all orthopaedic GAS infections at our medical centre between January 2017 and April 2019. Median age was 56 years. At least 60% had a body mass index (BMI) of ≥30 kg/m2. Median Charlson comorbidity score was 3 (range 0–7). Clinical cure at 90 days was achieved in only 62%. All 4 patients with underlying orthopaedic hardware were cured. Toxin-neutralizing antibiotics and intravenous immunoglobulin were underutilized. Our review confirms poor outcomes from GAS orthopaedic infections without optimal management.

KW - Group A streptococci (GAS)

KW - Hardware infection

KW - Necrotizing fasciitis

KW - Osteomyelitis

KW - Streptococcus pyogenes

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Beta-hemolytic group a streptococcal orthopaedic infections: Our institutional experience and review of the literature

Abstract

Keywords

ASJC Scopus subject areas

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