TY - JOUR
T1 - Behavioural response to m-chlorophenylpiperazine and clonidine in trichotillomania
AU - Stein, D. J.
AU - Hollander, E.
AU - De Carcia, C.
AU - Cohen, L.
AU - Simeon, D.
PY - 1997
Y1 - 1997
N2 - Administration of m-chlorophenyl-piperazine (m-CPP), a partial serotonin agonist, may lead to acute exacerbation of symptoms of obsessive-compulsive disorder (OCD), whereas administration of the alpha-2 adrenergic agonist, clonidine, may be followed by an acute decrease in symptoms. We studied behavioural response of 11 patients with trichotillomania, a disorder possibly related to OCD, to these agents and to placebo. No significant drug effects on specific trichotillomania symptoms were found. Patients experienced more of a 'high' feeling on m-CPP than on clonidine or placebo, a finding similar to that seen in patients with impulsive personality disorders.
AB - Administration of m-chlorophenyl-piperazine (m-CPP), a partial serotonin agonist, may lead to acute exacerbation of symptoms of obsessive-compulsive disorder (OCD), whereas administration of the alpha-2 adrenergic agonist, clonidine, may be followed by an acute decrease in symptoms. We studied behavioural response of 11 patients with trichotillomania, a disorder possibly related to OCD, to these agents and to placebo. No significant drug effects on specific trichotillomania symptoms were found. Patients experienced more of a 'high' feeling on m-CPP than on clonidine or placebo, a finding similar to that seen in patients with impulsive personality disorders.
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M3 - Article
AN - SCOPUS:0030839379
SN - 1350-7702
VL - 4
SP - 11
EP - 15
JO - Journal of Serotonin Research
JF - Journal of Serotonin Research
IS - 1
ER -