Abstract
The transcriptional repressor protein BCL-6, implicated in the pathogenesis of B cell lymphoma, regulates lymphocyte differentiation and inflammation. We investigated the mechanism for the T helper cell subset 2 (TH2)-type inflammation that occurs in BCL-6-/- mice. Using chimeric mice we found that the TH2-type inflammation is dependent upon nonlymphoid cells. We identified three chemokines, MCP-1, MCP-3 and MRP-1, which are negatively regulated by BCL-6 in macrophages. Promoter analysis revealed that BCL-6 is a potent repressor of MCP-1 transcription. Our results provide a mechanism for the regulation of TH2-type inflammation by BCL-6 and link TH2 differentiation to innate immunity.
Original language | English (US) |
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Pages (from-to) | 214-220 |
Number of pages | 7 |
Journal | Nature Immunology |
Volume | 1 |
Issue number | 3 |
DOIs | |
State | Published - Sep 2000 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology