Abstract
A new study demonstrates the tumorigenic functions of B7x and reveals a link between B7x and myeloid-derived suppressor cells (MDSCs) within the tumor microenvironment. We propose that the binding of B7x to a hitherto unidentified receptor on MDSCs may stimulate their proliferation and/or immunosuppressive functions, hence promoting tumor growth.
Original language | English (US) |
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Article number | e24744 |
Journal | OncoImmunology |
Volume | 2 |
Issue number | 7 |
DOIs | |
State | Published - 2013 |
Keywords
- B7x
- Immunosuppression
- Myeloid-derived suppressor cells
- Receptor
- Tumor microenvironment
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Oncology