B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization

Véronique Angeli; Florent Ginhoux; Jaime Llodrà; Laurence Quemeneur; Paul S. Frenette; Mihaela Skobe; Rolf Jessberger; Miriam Merad; Gwendalyn J. Randolph

doi:10.1016/j.immuni.2006.01.003

B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization

Véronique Angeli, Florent Ginhoux, Jaime Llodrà, Laurence Quemeneur, Paul S. Frenette, Mihaela Skobe, Rolf Jessberger, Miriam Merad, Gwendalyn J. Randolph

Research output: Contribution to journal › Article › peer-review

380 Scopus citations

Abstract

Dendritic cell (DC) migration from the periphery to lymph nodes is regulated by the pattern of genes expressed by DCs themselves and by signals within the surrounding peripheral environment. Here, we report that DC mobilization can also be regulated by signals initiated within the downstream lymph nodes, particularly when lymph nodes enlarge as a consequence of immunization. Lymph node B lymphocytes orchestrate expansion of the lymphatic network within the immunized lymph node. This expanded network in turn supports increased DC migration from the periphery. These results reveal unique relationships between B cells, lymphatic vessels, and migratory DCs. Knowledge that DC migration from the periphery is augmented by B cell-dependent signals reveals new potential strategies to increase DC migration during vaccination.

Original language	English (US)
Pages (from-to)	203-215
Number of pages	13
Journal	Immunity
Volume	24
Issue number	2
DOIs	https://doi.org/10.1016/j.immuni.2006.01.003
State	Published - Feb 2006
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.immuni.2006.01.003

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@article{6bde93ad4d034f7599c00bbf768a28ac,

title = "B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization",

abstract = "Dendritic cell (DC) migration from the periphery to lymph nodes is regulated by the pattern of genes expressed by DCs themselves and by signals within the surrounding peripheral environment. Here, we report that DC mobilization can also be regulated by signals initiated within the downstream lymph nodes, particularly when lymph nodes enlarge as a consequence of immunization. Lymph node B lymphocytes orchestrate expansion of the lymphatic network within the immunized lymph node. This expanded network in turn supports increased DC migration from the periphery. These results reveal unique relationships between B cells, lymphatic vessels, and migratory DCs. Knowledge that DC migration from the periphery is augmented by B cell-dependent signals reveals new potential strategies to increase DC migration during vaccination.",

author = "V{\'e}ronique Angeli and Florent Ginhoux and Jaime Llodr{\`a} and Laurence Quemeneur and Frenette, {Paul S.} and Mihaela Skobe and Rolf Jessberger and Miriam Merad and Randolph, {Gwendalyn J.}",

note = "Funding Information: We thank Dr. Troy Randall and Dr. Melody Swartz for helpful discussions; Dr. Jon Bromberg for MEL-14 mAb; and Dr. Bronislaw Pytowski and Dr. Daniel J. Hicklin for VEGFR-3 and VEGFR-2 mAbs, respectively. This work was funded by NIH grant HL69446 to G.J.R., a Scientist Development Grant from AHA (National Center) to V.A., and by Emerald Foundation to M.S. ",

year = "2006",

month = feb,

doi = "10.1016/j.immuni.2006.01.003",

language = "English (US)",

volume = "24",

pages = "203--215",

journal = "Immunity",

issn = "1074-7613",

publisher = "Cell Press",

number = "2",

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T1 - B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization

AU - Angeli, Véronique

AU - Ginhoux, Florent

AU - Llodrà, Jaime

AU - Quemeneur, Laurence

AU - Frenette, Paul S.

AU - Skobe, Mihaela

AU - Jessberger, Rolf

AU - Merad, Miriam

AU - Randolph, Gwendalyn J.

N1 - Funding Information: We thank Dr. Troy Randall and Dr. Melody Swartz for helpful discussions; Dr. Jon Bromberg for MEL-14 mAb; and Dr. Bronislaw Pytowski and Dr. Daniel J. Hicklin for VEGFR-3 and VEGFR-2 mAbs, respectively. This work was funded by NIH grant HL69446 to G.J.R., a Scientist Development Grant from AHA (National Center) to V.A., and by Emerald Foundation to M.S.

PY - 2006/2

Y1 - 2006/2

N2 - Dendritic cell (DC) migration from the periphery to lymph nodes is regulated by the pattern of genes expressed by DCs themselves and by signals within the surrounding peripheral environment. Here, we report that DC mobilization can also be regulated by signals initiated within the downstream lymph nodes, particularly when lymph nodes enlarge as a consequence of immunization. Lymph node B lymphocytes orchestrate expansion of the lymphatic network within the immunized lymph node. This expanded network in turn supports increased DC migration from the periphery. These results reveal unique relationships between B cells, lymphatic vessels, and migratory DCs. Knowledge that DC migration from the periphery is augmented by B cell-dependent signals reveals new potential strategies to increase DC migration during vaccination.

AB - Dendritic cell (DC) migration from the periphery to lymph nodes is regulated by the pattern of genes expressed by DCs themselves and by signals within the surrounding peripheral environment. Here, we report that DC mobilization can also be regulated by signals initiated within the downstream lymph nodes, particularly when lymph nodes enlarge as a consequence of immunization. Lymph node B lymphocytes orchestrate expansion of the lymphatic network within the immunized lymph node. This expanded network in turn supports increased DC migration from the periphery. These results reveal unique relationships between B cells, lymphatic vessels, and migratory DCs. Knowledge that DC migration from the periphery is augmented by B cell-dependent signals reveals new potential strategies to increase DC migration during vaccination.

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EP - 215

JO - Immunity

JF - Immunity

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ER -

B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization

Abstract

ASJC Scopus subject areas

UN SDGs

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