Autoradiographic localization of thyrotropin-releasing hormone receptors in amyotrophic lateral sclerosis spinal cord

Scott Manaker; Lisa H. Shulman; Andrew Winokur; Thomas C. Rainbow

doi:10.1212/wnl.35.11.1650

Autoradiographic localization of thyrotropin-releasing hormone receptors in amyotrophic lateral sclerosis spinal cord

Scott Manaker, Lisa H. Shulman, Andrew Winokur, Thomas C. Rainbow

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

We used quantitative autoradiography to determine the density of thyrotropin-releasing hormone (TRH) receptors in discrete regions of spinal cord from four Patients with amvotrophic lateral sclerosis [ALS]. The density and distribution of [³H]-3-methyl-histidine¹-TRH binding to TRH receptors differed from reported values in normal individuals, with fewer TRH receptors in lamina II and lamina IX. The diminished concentration of TRH receptors in lamina IX may reflect the loss of motor neurons in ALS.

Original language	English (US)
Pages (from-to)	1650-1653
Number of pages	4
Journal	Neurology
Volume	35
Issue number	11
DOIs	https://doi.org/10.1212/wnl.35.11.1650
State	Published - Nov 1985
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology

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abstract = "We used quantitative autoradiography to determine the density of thyrotropin-releasing hormone (TRH) receptors in discrete regions of spinal cord from four Patients with amvotrophic lateral sclerosis [ALS]. The density and distribution of [3H]-3-methyl-histidine1-TRH binding to TRH receptors differed from reported values in normal individuals, with fewer TRH receptors in lamina II and lamina IX. The diminished concentration of TRH receptors in lamina IX may reflect the loss of motor neurons in ALS.",

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AU - Winokur, Andrew

AU - Rainbow, Thomas C.

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AB - We used quantitative autoradiography to determine the density of thyrotropin-releasing hormone (TRH) receptors in discrete regions of spinal cord from four Patients with amvotrophic lateral sclerosis [ALS]. The density and distribution of [3H]-3-methyl-histidine1-TRH binding to TRH receptors differed from reported values in normal individuals, with fewer TRH receptors in lamina II and lamina IX. The diminished concentration of TRH receptors in lamina IX may reflect the loss of motor neurons in ALS.

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Autoradiographic localization of thyrotropin-releasing hormone receptors in amyotrophic lateral sclerosis spinal cord

Abstract

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