Autophagy and the immune function in aging

Ana Maria Cuervo, Fernando Macian

Research output: Contribution to journalReview articlepeer-review

92 Scopus citations


Just when you thought that you had heard it all about autophagy. -. the conserved cellular process that mediates turnover of cellular constituents in the lysosomes. -. studies keep coming out highlighting new types of autophagy, new functions for autophagy or even new autophagy-independent roles for the proteins associated with this process. The field of immunology has been riding the autophagic wave since the beginning of its revival; first due to its role in the host defense against pathogens, and more recently through the better understanding of the unique characteristics and functions of different autophagic pathways in immune cells. Here, we describe some of these new functions that are tightening the connection between autophagy and acquired or innate immunity and their malfunctioning with age.

Original languageEnglish (US)
Pages (from-to)97-104
Number of pages8
JournalCurrent Opinion in Immunology
Issue number1
StatePublished - Aug 2014

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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