TY - JOUR
T1 - Autoimmune Hepatitis
T2 - Diagnostic Dilemma When It Is Disguised as Iron Overload Syndrome
AU - Acharya, Gyanendra K.
AU - Liao, Hung I.
AU - Frunza-Stefan, Simona
AU - Patel, Ronakkumar
AU - Khaing, Moe
N1 - Publisher Copyright:
© 2017 INASL
PY - 2017/9
Y1 - 2017/9
N2 - Elevated serum ferritin level is a common finding in iron overload syndrome, autoimmune and viral hepatitis, alcoholic and nonalcoholic fatty liver diseases. High transferrin saturation is not a common finding in above diseases except for iron overload syndrome. We encountered a challenging case of 73-year-old female who presented with yellowish discoloration of skin, dark color urine and dull abdominal pain. Initial laboratory tests reported mild anemia; elevated bilirubin, liver enzymes, and transferrin saturation. We came to the final diagnosis of autoimmune hepatitis after extensive workups. Autoimmune hepatitis is a rare disease, and the diagnosis can be further complicated by a similar presentation of iron overload syndrome. Markedly elevated transferrin saturation can simulate iron overload syndrome, but a liver biopsy can guide physicians to navigate the diagnosis.
AB - Elevated serum ferritin level is a common finding in iron overload syndrome, autoimmune and viral hepatitis, alcoholic and nonalcoholic fatty liver diseases. High transferrin saturation is not a common finding in above diseases except for iron overload syndrome. We encountered a challenging case of 73-year-old female who presented with yellowish discoloration of skin, dark color urine and dull abdominal pain. Initial laboratory tests reported mild anemia; elevated bilirubin, liver enzymes, and transferrin saturation. We came to the final diagnosis of autoimmune hepatitis after extensive workups. Autoimmune hepatitis is a rare disease, and the diagnosis can be further complicated by a similar presentation of iron overload syndrome. Markedly elevated transferrin saturation can simulate iron overload syndrome, but a liver biopsy can guide physicians to navigate the diagnosis.
KW - Autoimmune disease
KW - Autoimmune hepatitis
KW - Diagnostic dilemma
KW - Iron overload syndrome
KW - Transferrin saturation
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U2 - 10.1016/j.jceh.2017.03.006
DO - 10.1016/j.jceh.2017.03.006
M3 - Article
AN - SCOPUS:85016718602
SN - 0973-6883
VL - 7
SP - 269
EP - 273
JO - Journal of Clinical and Experimental Hepatology
JF - Journal of Clinical and Experimental Hepatology
IS - 3
ER -