@article{e82788174a33491aab619b6960c8b4e8,
title = "Associations of hyperglycemia and insulin resistance with biomarkers of endothelial dysfunction in Hispanic/Latino youths: Results from the Hispanic Community Children's Health Study/Study of Latino Youth (SOL Youth)",
abstract = "Aims We hypothesized that Hispanic/Latino youth at high risk for diabetes would have elevated biomarkers of endothelial dysfunction. Methods Among 1316 children 8–16 years old from the Study of Latino Youth (SOL Youth), we used Poisson regression to obtain prevalence ratios (PRs) and 95% CIs for the cross-sectional association of quartiles of fasting glucose, HbA1c, and insulin resistance with E-selectin and plasminogen activator inhibitor-1 (PAI-1) levels above the median (≥ 48.1 and ≥ 2.02 ng/mL, respectively). Results Levels of E-selectin and PAI-1 were higher in children who were obese or had higher levels of hs-CRP (p < 0.05). Insulin resistance was independently associated with higher levels of PAI-1 (adjusted PR and 95% CI for the highest versus lowest quartile (Q4 vs Q1): 2.25 [1.64, 3.09]). We found stronger evidence of associations of insulin resistance with higher levels of PAI-1 among boys as compared with girls (p-interaction = 0.10). Conclusions Insulin resistance was associated with endothelial dysfunction, as measured by higher levels of PAI-1, in Hispanic/Latino youth. These biomarkers may be useful in risk stratification and prediction of diabetes and cardiovascular disease in high-risk youth.",
keywords = "Adolescents/children, E-selectin, Hispanics, Hyyperglycemia, Insulin resistance, Plasminogen activator inhibitor-1",
author = "Parrinello, {Christina M.} and Simin Hua and Carnethon, {Mercedes R.} and Gallo, {Linda C.} and Hudson, {Barry I.} and Goldberg, {Ronald B.} and Delamater, {Alan M.} and Kaplan, {Robert C.} and Isasi, {Carmen R.}",
note = "Funding Information: The SOL Youth Study was supported by Grant Number R01HL102130 from the National Heart, Lung, and Blood Institute. The children in SOL Youth are drawn from the study of adults: The Hispanic Community Health Study/Study of Latinos, which was supported by contracts from the National Heart, Lung, and Blood Institute (NHLBI) to the University of North Carolina (N01-HC65233), University of Miami (N01-HC65234), Albert Einstein College of Medicine (N01-HC65235), Northwestern University (N01-HC65236), and San Diego State University (N01-HC65237). The following Institutes/Centers/Offices contribute to the HCHS/SOL through a transfer of funds to NHLBI: National Center on Minority Health and Health Disparities, the National Institute of Deafness and Other Communications Disorders, the National Institute of Dental and Craniofacial Research, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute of Neurological Disorders and Stroke, and the Office of Dietary Supplements. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Heart, Lung, and Blood Institute or the National Institutes of Health. Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",
year = "2017",
month = may,
doi = "10.1016/j.jdiacomp.2017.01.019",
language = "English (US)",
volume = "31",
pages = "836--842",
journal = "Journal of Diabetes and Its Complications",
issn = "1056-8727",
publisher = "Elsevier Inc.",
number = "5",
}
