Association of total insulin-like growth factor-I, insulin-like growth factor binding protein-1 (IGFBP-1), and IGFBP-3 levels with incident coronary events and ischemic stroke

Robert C. Kaplan; Aileen P. McGinn; Michael N. Pollak; Lewis H. Kuller; Howard D. Strickler; Tom E. Rohan; Anne R. Cappola; Xiao Nan Xue; Bruce M. Psaty

doi:10.1210/jc.2006-1631

Association of total insulin-like growth factor-I, insulin-like growth factor binding protein-1 (IGFBP-1), and IGFBP-3 levels with incident coronary events and ischemic stroke

Robert C. Kaplan, Aileen P. McGinn, Michael N. Pollak, Lewis H. Kuller, Howard D. Strickler, Tom E. Rohan, Anne R. Cappola, Xiao Nan Xue, Bruce M. Psaty

Epidemiology & Population Health

Research output: Contribution to journal › Article › peer-review

107 Scopus citations

Abstract

Context: Prior observational studies have demonstrated that the GH/IGF axis is associated with cardiovascular disease. However, this association has not been extensively studied among older adults. Objective: The objective of this study was to assess the association between levels of total IGF-I and IGF binding proteins (IGFBP-1, IGFBP-3) and risk of incident coronary events and ischemic stroke. Design and Participants: A case-cohort analysis was conducted among adults 65 yr and older in the Cardiovascular Health Study. Main Outcome Measures: A total of 534 coronary events [316 nonfatal myocardial infarctions (MIs), 48 fatal MIs, and 170 fatal coronary heart disease events] and 370 ischemic strokes were identified on follow-up. Comparison subjects were 1122 randomly selected participants from the Cardiovascular Health Study. Results: Mean follow-up time was 6.7 yr for coronary events, 5.6 yr for strokes, and 9.3 yr for comparison subjects. Hazard ratios (95% confidence intervals) associated with baseline levels of total IGF-I and IGFBPs were estimated using multivariate adjusted Cox proportional hazards models. Neither IGF-I nor IGFBP-1 levels predicted risk of incident coronary events or stroke. IGFBP-3 had an inverse association with risk of coronary events [adjusted hazard ratio per SD = 0.88 (0.78 -1.00), P = 0.05] but was not associated with stroke. Exploratory analyses suggested that low IGF-I and low IGFBP-3 levels were significantly associated with higher risk of nonfatal MI (P < 0.05) but not with risk of fatal MI or fatal coronary heart disease. Conclusion: Circulating levels of total IGF-I or IGFBP-1 were not associated with risk of total coronary events or ischemic stroke among older adults, whereas low IGFBP-3 level was associated with increased risk of incident coronary events.

Original language	English (US)
Pages (from-to)	1319-1325
Number of pages	7
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	92
Issue number	4
DOIs	https://doi.org/10.1210/jc.2006-1631
State	Published - Apr 2007

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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10.1210/jc.2006-1631

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Kaplan, R. C., McGinn, A. P., Pollak, M. N., Kuller, L. H., Strickler, H. D., Rohan, T. E., Cappola, A. R., Xue, X. N., & Psaty, B. M. (2007). Association of total insulin-like growth factor-I, insulin-like growth factor binding protein-1 (IGFBP-1), and IGFBP-3 levels with incident coronary events and ischemic stroke. Journal of Clinical Endocrinology and Metabolism, 92(4), 1319-1325. https://doi.org/10.1210/jc.2006-1631

Association of total insulin-like growth factor-I, insulin-like growth factor binding protein-1 (IGFBP-1), and IGFBP-3 levels with incident coronary events and ischemic stroke. / Kaplan, Robert C.; McGinn, Aileen P.; Pollak, Michael N. et al.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 92, No. 4, 04.2007, p. 1319-1325.

Research output: Contribution to journal › Article › peer-review

Kaplan, RC , McGinn, AP, Pollak, MN, Kuller, LH, Strickler, HD , Rohan, TE, Cappola, AR, Xue, XN & Psaty, BM 2007, 'Association of total insulin-like growth factor-I, insulin-like growth factor binding protein-1 (IGFBP-1), and IGFBP-3 levels with incident coronary events and ischemic stroke', Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 4, pp. 1319-1325. https://doi.org/10.1210/jc.2006-1631

@article{cd45b4dddf7c4264951d629bc6ab39e1,

title = "Association of total insulin-like growth factor-I, insulin-like growth factor binding protein-1 (IGFBP-1), and IGFBP-3 levels with incident coronary events and ischemic stroke",

abstract = "Context: Prior observational studies have demonstrated that the GH/IGF axis is associated with cardiovascular disease. However, this association has not been extensively studied among older adults. Objective: The objective of this study was to assess the association between levels of total IGF-I and IGF binding proteins (IGFBP-1, IGFBP-3) and risk of incident coronary events and ischemic stroke. Design and Participants: A case-cohort analysis was conducted among adults 65 yr and older in the Cardiovascular Health Study. Main Outcome Measures: A total of 534 coronary events [316 nonfatal myocardial infarctions (MIs), 48 fatal MIs, and 170 fatal coronary heart disease events] and 370 ischemic strokes were identified on follow-up. Comparison subjects were 1122 randomly selected participants from the Cardiovascular Health Study. Results: Mean follow-up time was 6.7 yr for coronary events, 5.6 yr for strokes, and 9.3 yr for comparison subjects. Hazard ratios (95% confidence intervals) associated with baseline levels of total IGF-I and IGFBPs were estimated using multivariate adjusted Cox proportional hazards models. Neither IGF-I nor IGFBP-1 levels predicted risk of incident coronary events or stroke. IGFBP-3 had an inverse association with risk of coronary events [adjusted hazard ratio per SD = 0.88 (0.78 -1.00), P = 0.05] but was not associated with stroke. Exploratory analyses suggested that low IGF-I and low IGFBP-3 levels were significantly associated with higher risk of nonfatal MI (P < 0.05) but not with risk of fatal MI or fatal coronary heart disease. Conclusion: Circulating levels of total IGF-I or IGFBP-1 were not associated with risk of total coronary events or ischemic stroke among older adults, whereas low IGFBP-3 level was associated with increased risk of incident coronary events.",

author = "Kaplan, {Robert C.} and McGinn, {Aileen P.} and Pollak, {Michael N.} and Kuller, {Lewis H.} and Strickler, {Howard D.} and Rohan, {Tom E.} and Cappola, {Anne R.} and Xue, {Xiao Nan} and Psaty, {Bruce M.}",

note = "Funding Information: This work was supported by contracts N01-HC-85079 through N01-HC-85086, N01-HC-35129, and N01 HC-15103 and grant R01HL075516-01 from the National Heart, Lung, and Blood Institute. Funding Information: Disclosure Statement: R.C.K. is Principal Investigator on a National Institutes of Health grant that supported this research. A.P.M., M.N.P., L.H.K., H.D.S., T.E.R., A.R.C., X.X., and B.M.P. have nothing to declare. ",

year = "2007",

month = apr,

doi = "10.1210/jc.2006-1631",

language = "English (US)",

volume = "92",

pages = "1319--1325",

journal = "Journal of Clinical Endocrinology and Metabolism",

issn = "0021-972X",

publisher = "The Endocrine Society",

number = "4",

}

TY - JOUR

T1 - Association of total insulin-like growth factor-I, insulin-like growth factor binding protein-1 (IGFBP-1), and IGFBP-3 levels with incident coronary events and ischemic stroke

AU - Kaplan, Robert C.

AU - McGinn, Aileen P.

AU - Pollak, Michael N.

AU - Kuller, Lewis H.

AU - Strickler, Howard D.

AU - Rohan, Tom E.

AU - Cappola, Anne R.

AU - Xue, Xiao Nan

AU - Psaty, Bruce M.

N1 - Funding Information: This work was supported by contracts N01-HC-85079 through N01-HC-85086, N01-HC-35129, and N01 HC-15103 and grant R01HL075516-01 from the National Heart, Lung, and Blood Institute. Funding Information: Disclosure Statement: R.C.K. is Principal Investigator on a National Institutes of Health grant that supported this research. A.P.M., M.N.P., L.H.K., H.D.S., T.E.R., A.R.C., X.X., and B.M.P. have nothing to declare.

PY - 2007/4

Y1 - 2007/4

N2 - Context: Prior observational studies have demonstrated that the GH/IGF axis is associated with cardiovascular disease. However, this association has not been extensively studied among older adults. Objective: The objective of this study was to assess the association between levels of total IGF-I and IGF binding proteins (IGFBP-1, IGFBP-3) and risk of incident coronary events and ischemic stroke. Design and Participants: A case-cohort analysis was conducted among adults 65 yr and older in the Cardiovascular Health Study. Main Outcome Measures: A total of 534 coronary events [316 nonfatal myocardial infarctions (MIs), 48 fatal MIs, and 170 fatal coronary heart disease events] and 370 ischemic strokes were identified on follow-up. Comparison subjects were 1122 randomly selected participants from the Cardiovascular Health Study. Results: Mean follow-up time was 6.7 yr for coronary events, 5.6 yr for strokes, and 9.3 yr for comparison subjects. Hazard ratios (95% confidence intervals) associated with baseline levels of total IGF-I and IGFBPs were estimated using multivariate adjusted Cox proportional hazards models. Neither IGF-I nor IGFBP-1 levels predicted risk of incident coronary events or stroke. IGFBP-3 had an inverse association with risk of coronary events [adjusted hazard ratio per SD = 0.88 (0.78 -1.00), P = 0.05] but was not associated with stroke. Exploratory analyses suggested that low IGF-I and low IGFBP-3 levels were significantly associated with higher risk of nonfatal MI (P < 0.05) but not with risk of fatal MI or fatal coronary heart disease. Conclusion: Circulating levels of total IGF-I or IGFBP-1 were not associated with risk of total coronary events or ischemic stroke among older adults, whereas low IGFBP-3 level was associated with increased risk of incident coronary events.

AB - Context: Prior observational studies have demonstrated that the GH/IGF axis is associated with cardiovascular disease. However, this association has not been extensively studied among older adults. Objective: The objective of this study was to assess the association between levels of total IGF-I and IGF binding proteins (IGFBP-1, IGFBP-3) and risk of incident coronary events and ischemic stroke. Design and Participants: A case-cohort analysis was conducted among adults 65 yr and older in the Cardiovascular Health Study. Main Outcome Measures: A total of 534 coronary events [316 nonfatal myocardial infarctions (MIs), 48 fatal MIs, and 170 fatal coronary heart disease events] and 370 ischemic strokes were identified on follow-up. Comparison subjects were 1122 randomly selected participants from the Cardiovascular Health Study. Results: Mean follow-up time was 6.7 yr for coronary events, 5.6 yr for strokes, and 9.3 yr for comparison subjects. Hazard ratios (95% confidence intervals) associated with baseline levels of total IGF-I and IGFBPs were estimated using multivariate adjusted Cox proportional hazards models. Neither IGF-I nor IGFBP-1 levels predicted risk of incident coronary events or stroke. IGFBP-3 had an inverse association with risk of coronary events [adjusted hazard ratio per SD = 0.88 (0.78 -1.00), P = 0.05] but was not associated with stroke. Exploratory analyses suggested that low IGF-I and low IGFBP-3 levels were significantly associated with higher risk of nonfatal MI (P < 0.05) but not with risk of fatal MI or fatal coronary heart disease. Conclusion: Circulating levels of total IGF-I or IGFBP-1 were not associated with risk of total coronary events or ischemic stroke among older adults, whereas low IGFBP-3 level was associated with increased risk of incident coronary events.

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Association of total insulin-like growth factor-I, insulin-like growth factor binding protein-1 (IGFBP-1), and IGFBP-3 levels with incident coronary events and ischemic stroke

Abstract

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