TY - JOUR
T1 - Association of endothelial nitric oxide synthase (enos) gene polymorphisms and physical fitness levels with plasma nitrite concentrations and arterial blood pressure values in older adults
AU - Da Silva, Roberta Fernanda
AU - Trapé, A. Tila Alexandre
AU - Reia, Thaís Amanda
AU - Lacchini, Riccardo
AU - Oliveira-Paula, Gustavo Henrique
AU - Pinheiro, Lucas Cezar
AU - Tanus-Santos, José Eduardo
AU - Jacomini, André Mourão
AU - Jú Nior, Carlos Roberto Bueno
AU - Zago, Anderson Saranz
N1 - Publisher Copyright:
© 2018 da Silva et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2018/10
Y1 - 2018/10
N2 - Endothelial nitric oxide synthase (eNOS) gene polymorphisms are associated with reduced eNOS activity and nitric oxide (NO) production leading to an increase in blood pressure (BP). Regular exercise is the main strategy to minimize the deleterious effects of polymorphisms. However, due to the differences that physical exercise can be performed, some controversial results are found. Therefore it seems reasonable to evaluate the training status (TS). Thus, this study aimed to investigate the association of eNOS gene haplotypes and different levels of TS on nitrite concentrations (NO2-) and BP values in older adult. 424 elderly performed the following assessments: General Functional Fitness Index (GFFI) to estimate TS, systolic and diastolic blood pressure (SBP and DBP), blood collection for analysis of NO2-and g.-786T>C, intron 4b/a (VNTR) and 894G>T polymorphisms. Multivariate logistic regression showed that NO2-was influenced by GFFI and 4b/4a Intron 4. RegardingBP, GFFI influenced SBP and DBP, and just intron 4 was associated with variations in DBP. It can be observed that GFFI affected the NO2-, SBP and DBP independently of haplotypes. Therefore, maintenance of good level of TS can overcome the negative influence of genetics factors (intron 4) by increasing NO2-concentration and decreasing BP values.
AB - Endothelial nitric oxide synthase (eNOS) gene polymorphisms are associated with reduced eNOS activity and nitric oxide (NO) production leading to an increase in blood pressure (BP). Regular exercise is the main strategy to minimize the deleterious effects of polymorphisms. However, due to the differences that physical exercise can be performed, some controversial results are found. Therefore it seems reasonable to evaluate the training status (TS). Thus, this study aimed to investigate the association of eNOS gene haplotypes and different levels of TS on nitrite concentrations (NO2-) and BP values in older adult. 424 elderly performed the following assessments: General Functional Fitness Index (GFFI) to estimate TS, systolic and diastolic blood pressure (SBP and DBP), blood collection for analysis of NO2-and g.-786T>C, intron 4b/a (VNTR) and 894G>T polymorphisms. Multivariate logistic regression showed that NO2-was influenced by GFFI and 4b/4a Intron 4. RegardingBP, GFFI influenced SBP and DBP, and just intron 4 was associated with variations in DBP. It can be observed that GFFI affected the NO2-, SBP and DBP independently of haplotypes. Therefore, maintenance of good level of TS can overcome the negative influence of genetics factors (intron 4) by increasing NO2-concentration and decreasing BP values.
UR - https://www.scopus.com/pages/publications/85055072733
UR - https://www.scopus.com/pages/publications/85055072733#tab=citedBy
U2 - 10.1371/journal.pone.0206254
DO - 10.1371/journal.pone.0206254
M3 - Article
C2 - 30335864
AN - SCOPUS:85055072733
SN - 1932-6203
VL - 13
JO - PloS one
JF - PloS one
IS - 10
M1 - e0206254
ER -