Assessment of Bone Perfusion with Contrast-Enhanced Magnetic Resonance Imaging

Jonathan H. Lee, Jonathan P. Dyke, Douglas Ballon, Deborah Mc K. Ciombor, Glenn Tung, Roy K. Aaron

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations


Osteoarthritis and avascular necrosis are common clinical entities with unknown origins. Recently, vascular changes were implicated in the pathogenesis of both conditions. This article discusses the use of novel noninvasive imaging techniques as a means of assessing bone perfusion and quantifying differences seen in osteoarthritis and avascular necrosis. Review of our human data suggests that the MRI contrast dye is retained for longer periods of time, suggesting decreased perfusion out of regions of osteoarthritis and avascular necrosis. Use of such a noninvasive measure of assessing bone perfusion could be useful in the diagnosis, prevention, and treatment of not only osteoarthritis and avascular necrosis but also other entities that affect the musculoskeletal system.

Original languageEnglish (US)
Pages (from-to)249-257
Number of pages9
JournalOrthopedic Clinics of North America
Issue number2
StatePublished - Apr 2009
Externally publishedYes


  • Animal model
  • Guinea pig
  • MRI
  • Osteoarthritis
  • Subchondral
  • Venous outflow occlusion

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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