Abstract
Non-steroidal Anti-inflammatory drugs (NSAID)-exacerbated respiratory disease (N-ERD) is characterized by nasal polyposis, chronic rhinosinusitis, adult-onset asthma and hypersensitive reactions to cyclooxygenase-1 (COX-1) inhibitors. Among the available treatments for this disease, a combination of endoscopic sinus surgery followed by aspirin desensitization and aspirin maintenance therapy has been an effective approach. Studies have shown that long-term aspirin maintenance therapy can reduce the rate of nasal polyp recurrence in patients with N-ERD. However, the exact mechanism by which aspirin can both trigger and suppress airway disease in N-ERD remains poorly understood. In this review, we summarize current knowledge of aspirin effects in N-ERD, cardiovascular disease, and cancer, and consider potential mechanistic pathways accounting for the effects of aspirin in N-ERD.
Original language | English (US) |
---|---|
Article number | 695815 |
Journal | Frontiers in immunology |
Volume | 12 |
DOIs | |
State | Published - Jun 25 2021 |
Keywords
- COX-1 inhibitor
- N-ERD
- NSAIDs
- aspirin
- leukotrienes
- lipoxins
- nasal polyps
- prostaglandins
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology