Aspirin Actions in Treatment of NSAID-Exacerbated Respiratory Disease

Esha Sehanobish, Mohammad Asad, Mali Barbi, Steven A. Porcelli, Elina Jerschow

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Non-steroidal Anti-inflammatory drugs (NSAID)-exacerbated respiratory disease (N-ERD) is characterized by nasal polyposis, chronic rhinosinusitis, adult-onset asthma and hypersensitive reactions to cyclooxygenase-1 (COX-1) inhibitors. Among the available treatments for this disease, a combination of endoscopic sinus surgery followed by aspirin desensitization and aspirin maintenance therapy has been an effective approach. Studies have shown that long-term aspirin maintenance therapy can reduce the rate of nasal polyp recurrence in patients with N-ERD. However, the exact mechanism by which aspirin can both trigger and suppress airway disease in N-ERD remains poorly understood. In this review, we summarize current knowledge of aspirin effects in N-ERD, cardiovascular disease, and cancer, and consider potential mechanistic pathways accounting for the effects of aspirin in N-ERD.

Original languageEnglish (US)
Article number695815
JournalFrontiers in immunology
StatePublished - Jun 25 2021


  • COX-1 inhibitor
  • N-ERD
  • NSAIDs
  • aspirin
  • leukotrienes
  • lipoxins
  • nasal polyps
  • prostaglandins

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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