Arginine and endothelial function

Jessica Gambardella; Wafiq Khondkar; Marco Bruno Morelli; Xujun Wang; Gaetano Santulli; Valentina Trimarco

doi:10.3390/BIOMEDICINES8080277

Arginine and endothelial function

Jessica Gambardella, Wafiq Khondkar, Marco Bruno Morelli, Xujun Wang, Gaetano Santulli, Valentina Trimarco

Medicine

Research output: Contribution to journal › Review article › peer-review

95 Scopus citations

Abstract

Arginine (L-arginine), is an amino acid involved in a number of biological processes, including the biosynthesis of proteins, host immune response, urea cycle, and nitric oxide production. In this systematic review, we focus on the functional role of arginine in the regulation of endothelial function and vascular tone. Both clinical and preclinical studies are examined, analyzing the effects of arginine supplementation in hypertension, ischemic heart disease, aging, peripheral artery disease, and diabetes mellitus.

Original language	English (US)
Article number	277
Journal	Biomedicines
Volume	8
Issue number	8
DOIs	https://doi.org/10.3390/BIOMEDICINES8080277
State	Published - Aug 2020

Keywords

ADMA
Arginine
Arginine paradox
BH4
Blood pressure
COVID-19
Dietary supplements
Endothelial dysfunction
Endothelium
Heart failure
Hypertension
L-arginine
Myocardial infarction
NADPH
Nitric oxide
Oxidative stress
Peripheral artery disease
eNOS uncoupling

ASJC Scopus subject areas

Medicine (miscellaneous)
Biochemistry, Genetics and Molecular Biology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/BIOMEDICINES8080277

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title = "Arginine and endothelial function",

abstract = "Arginine (L-arginine), is an amino acid involved in a number of biological processes, including the biosynthesis of proteins, host immune response, urea cycle, and nitric oxide production. In this systematic review, we focus on the functional role of arginine in the regulation of endothelial function and vascular tone. Both clinical and preclinical studies are examined, analyzing the effects of arginine supplementation in hypertension, ischemic heart disease, aging, peripheral artery disease, and diabetes mellitus.",

keywords = "ADMA, Arginine, Arginine paradox, BH4, Blood pressure, COVID-19, Dietary supplements, Endothelial dysfunction, Endothelium, Heart failure, Hypertension, L-arginine, Myocardial infarction, NADPH, Nitric oxide, Oxidative stress, Peripheral artery disease, eNOS uncoupling",

author = "Jessica Gambardella and Wafiq Khondkar and Morelli, {Marco Bruno} and Xujun Wang and Gaetano Santulli and Valentina Trimarco",

note = "Funding Information: Funding: The Santulli{\textquoteright}s lab is supported in part by the NIH (R01-DK123259, R01-HL146691, R01-DK033823, and R00-DK107895 to G.S.) and by the American Heart Association (AHA-20POST35211151 to J.G.). Publisher Copyright: {\textcopyright} 2020 by the authors.",

year = "2020",

month = aug,

doi = "10.3390/BIOMEDICINES8080277",

language = "English (US)",

volume = "8",

journal = "Biomedicines",

issn = "2227-9059",

publisher = "MDPI AG",

number = "8",

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TY - JOUR

T1 - Arginine and endothelial function

AU - Gambardella, Jessica

AU - Khondkar, Wafiq

AU - Morelli, Marco Bruno

AU - Wang, Xujun

AU - Santulli, Gaetano

AU - Trimarco, Valentina

N1 - Funding Information: Funding: The Santulli’s lab is supported in part by the NIH (R01-DK123259, R01-HL146691, R01-DK033823, and R00-DK107895 to G.S.) and by the American Heart Association (AHA-20POST35211151 to J.G.). Publisher Copyright: © 2020 by the authors.

PY - 2020/8

Y1 - 2020/8

N2 - Arginine (L-arginine), is an amino acid involved in a number of biological processes, including the biosynthesis of proteins, host immune response, urea cycle, and nitric oxide production. In this systematic review, we focus on the functional role of arginine in the regulation of endothelial function and vascular tone. Both clinical and preclinical studies are examined, analyzing the effects of arginine supplementation in hypertension, ischemic heart disease, aging, peripheral artery disease, and diabetes mellitus.

AB - Arginine (L-arginine), is an amino acid involved in a number of biological processes, including the biosynthesis of proteins, host immune response, urea cycle, and nitric oxide production. In this systematic review, we focus on the functional role of arginine in the regulation of endothelial function and vascular tone. Both clinical and preclinical studies are examined, analyzing the effects of arginine supplementation in hypertension, ischemic heart disease, aging, peripheral artery disease, and diabetes mellitus.

KW - ADMA

KW - Arginine

KW - Arginine paradox

KW - BH4

KW - Blood pressure

KW - COVID-19

KW - Dietary supplements

KW - Endothelial dysfunction

KW - Endothelium

KW - Heart failure

KW - Hypertension

KW - L-arginine

KW - Myocardial infarction

KW - NADPH

KW - Nitric oxide

KW - Oxidative stress

KW - Peripheral artery disease

KW - eNOS uncoupling

UR - http://www.scopus.com/inward/record.url?scp=85089830839&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85089830839&partnerID=8YFLogxK

U2 - 10.3390/BIOMEDICINES8080277

DO - 10.3390/BIOMEDICINES8080277

M3 - Review article

AN - SCOPUS:85089830839

SN - 2227-9059

VL - 8

JO - Biomedicines

JF - Biomedicines

IS - 8

M1 - 277

ER -

Arginine and endothelial function

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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