Arginine and endothelial function

Jessica Gambardella, Wafiq Khondkar, Marco Bruno Morelli, Xujun Wang, Gaetano Santulli, Valentina Trimarco

Research output: Contribution to journalReview articlepeer-review

95 Scopus citations


Arginine (L-arginine), is an amino acid involved in a number of biological processes, including the biosynthesis of proteins, host immune response, urea cycle, and nitric oxide production. In this systematic review, we focus on the functional role of arginine in the regulation of endothelial function and vascular tone. Both clinical and preclinical studies are examined, analyzing the effects of arginine supplementation in hypertension, ischemic heart disease, aging, peripheral artery disease, and diabetes mellitus.

Original languageEnglish (US)
Article number277
Issue number8
StatePublished - Aug 2020


  • ADMA
  • Arginine
  • Arginine paradox
  • BH4
  • Blood pressure
  • COVID-19
  • Dietary supplements
  • Endothelial dysfunction
  • Endothelium
  • Heart failure
  • Hypertension
  • L-arginine
  • Myocardial infarction
  • Nitric oxide
  • Oxidative stress
  • Peripheral artery disease
  • eNOS uncoupling

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)


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