Approaches for calculating power for case-cohort studies

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


An approach for determining the power of a case-cohort study for a single binary exposure variable and a low failure rate was recently proposed by Cai and Zeng (2004, Biometrics 60, 1015-1024). In this article, we show that computing power for a case-cohort study using a standard case-control method yields nearly identical levels of power. An advantage of the case-control approach is that existing sample size software can be used for the calculations. We also propose an additional formula for computing the power of a case-cohort study for the situation when the event is not rare.

Original languageEnglish (US)
Pages (from-to)929-933
Number of pages5
Issue number3
StatePublished - Sep 2006


  • Case-cohort design
  • Power
  • Sample size

ASJC Scopus subject areas

  • Statistics and Probability
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics


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