Apoptotic cell death in disease—Current understanding of the NCCD 2023

Ilio Vitale; Federico Pietrocola; Emma Guilbaud; Stuart A. Aaronson; John M. Abrams; Dieter Adam; Massimiliano Agostini; Patrizia Agostinis; Emad S. Alnemri; Lucia Altucci; Ivano Amelio; David W. Andrews; Rami I. Aqeilan; Eli Arama; Eric H. Baehrecke; Siddharth Balachandran; Daniele Bano; Nickolai A. Barlev; Jiri Bartek; Nicolas G. Bazan; Christoph Becker; Francesca Bernassola; Mathieu J.M. Bertrand; Marco E. Bianchi; Mikhail V. Blagosklonny; J. Magarian Blander; Giovanni Blandino; Klas Blomgren; Christoph Borner; Carl D. Bortner; Pierluigi Bove; Patricia Boya; Catherine Brenner; Petr Broz; Thomas Brunner; Rune Busk Damgaard; George A. Calin; Michelangelo Campanella; Eleonora Candi; Michele Carbone; Didac Carmona-Gutierrez; Francesco Cecconi; Francis K.M. Chan; Guo Qiang Chen; Quan Chen; Youhai H. Chen; Emily H. Cheng; Jerry E. Chipuk; John A. Cidlowski; Aaron Ciechanover; Gennaro Ciliberto; Marcus Conrad; Juan R. Cubillos-Ruiz; Peter E. Czabotar; Vincenzo D’Angiolella; Mads Daugaard; Ted M. Dawson; Valina L. Dawson; Ruggero De Maria; Bart De Strooper; Klaus Michael Debatin; Ralph J. Deberardinis; Alexei Degterev; Giannino Del Sal; Mohanish Deshmukh; Francesco Di Virgilio; Marc Diederich; Scott J. Dixon; Brian D. Dynlacht; Wafik S. El-Deiry; John W. Elrod; Kurt Engeland; Gian Maria Fimia; Claudia Galassi; Carlo Ganini; Ana J. Garcia-Saez; Abhishek D. Garg; Carmen Garrido; Evripidis Gavathiotis; Motti Gerlic; Sourav Ghosh; Douglas R. Green; Lloyd A. Greene; Hinrich Gronemeyer; Georg Häcker; György Hajnóczky; J. Marie Hardwick; Ygal Haupt; Sudan He; David M. Heery; Michael O. Hengartner; Claudio Hetz; David A. Hildeman; Hidenori Ichijo; Satoshi Inoue; Marja Jäättelä; Ana Janic; Bertrand Joseph; Philipp J. Jost; Thirumala Devi Kanneganti; Michael Karin; Hamid Kashkar; Thomas Kaufmann; Gemma L. Kelly; Oliver Kepp; Adi Kimchi; Richard N. Kitsis; Daniel J. Klionsky; Ruth Kluck; Dmitri V. Krysko; Dagmar Kulms; Sharad Kumar; Sergio Lavandero; Inna N. Lavrik; John J. Lemasters; Gianmaria Liccardi; Andreas Linkermann; Stuart A. Lipton; Richard A. Lockshin; Carlos López-Otín; Tom Luedde; Marion MacFarlane; Frank Madeo; Walter Malorni; Gwenola Manic; Roberto Mantovani; Saverio Marchi; Jean Christophe Marine; Seamus J. Martin; Jean Claude Martinou; Pier G. Mastroberardino; Jan Paul Medema; Patrick Mehlen; Pascal Meier; Gerry Melino; Sonia Melino; Edward A. Miao; Ute M. Moll; Cristina Muñoz-Pinedo; Daniel J. Murphy; Maria Victoria Niklison-Chirou; Flavia Novelli; Gabriel Núñez; Andrew Oberst; Dimitry Ofengeim; Joseph T. Opferman; Moshe Oren; Michele Pagano; Theocharis Panaretakis; Manolis Pasparakis; Josef M. Penninger; Francesca Pentimalli; David M. Pereira; Shazib Pervaiz; Marcus E. Peter; Paolo Pinton; Giovanni Porta; Jochen H.M. Prehn; Hamsa Puthalakath; Gabriel A. Rabinovich; Krishnaraj Rajalingam; Kodi S. Ravichandran; Markus Rehm; Jean Ehrland Ricci; Rosario Rizzuto; Nirmal Robinson; Cecilia M.P. Rodrigues; Barak Rotblat; Carla V. Rothlin; David C. Rubinsztein; Thomas Rudel; Alessandro Rufini; Kevin M. Ryan; Kristopher A. Sarosiek; Akira Sawa; Emre Sayan; Kate Schroder; Luca Scorrano; Federico Sesti; Feng Shao; Yufang Shi; Giuseppe S. Sica; John Silke; Hans Uwe Simon; Antonella Sistigu; Anastasis Stephanou; Brent R. Stockwell; Flavie Strapazzon; Andreas Strasser; Liming Sun; Erwei Sun; Qiang Sun; Gyorgy Szabadkai; Stephen W.G. Tait; Daolin Tang; Nektarios Tavernarakis; Carol M. Troy; Boris Turk; Nicoletta Urbano; Peter Vandenabeele; Tom Vanden Berghe; Matthew G. Vander Heiden; Jacqueline L. Vanderluit; Alexei Verkhratsky; Andreas Villunger; Silvia von Karstedt; Anne K. Voss; Karen H. Vousden; Domagoj Vucic; Daniela Vuri; Erwin F. Wagner; Henning Walczak; David Wallach; Ruoning Wang; Ying Wang; Achim Weber; Will Wood; Takahiro Yamazaki; Huang Tian Yang; Zahra Zakeri; Joanna E. Zawacka-Pankau; Lin Zhang; Haibing Zhang; Boris Zhivotovsky; Wenzhao Zhou; Mauro Piacentini; Guido Kroemer; Lorenzo Galluzzi

doi:10.1038/s41418-023-01153-w

Apoptotic cell death in disease—Current understanding of the NCCD 2023

Ilio Vitale, Federico Pietrocola, Emma Guilbaud, Stuart A. Aaronson, John M. Abrams, Dieter Adam, Massimiliano Agostini, Patrizia Agostinis, Emad S. Alnemri, Lucia Altucci, Ivano Amelio, David W. Andrews, Rami I. Aqeilan, Eli Arama, Eric H. Baehrecke, Siddharth Balachandran, Daniele Bano, Nickolai A. Barlev, Jiri Bartek, Nicolas G. BazanChristoph Becker, Francesca Bernassola, Mathieu J.M. Bertrand, Marco E. Bianchi, Mikhail V. Blagosklonny, J. Magarian Blander, Giovanni Blandino, Klas Blomgren, Christoph Borner, Carl D. Bortner, Pierluigi Bove, Patricia Boya, Catherine Brenner, Petr Broz, Thomas Brunner, Rune Busk Damgaard, George A. Calin, Michelangelo Campanella, Eleonora Candi, Michele Carbone, Didac Carmona-Gutierrez, Francesco Cecconi, Francis K.M. Chan, Guo Qiang Chen, Quan Chen, Youhai H. Chen, Emily H. Cheng, Jerry E. Chipuk, John A. Cidlowski, Aaron Ciechanover, Gennaro Ciliberto, Marcus Conrad, Juan R. Cubillos-Ruiz, Peter E. Czabotar, Vincenzo D’Angiolella, Mads Daugaard, Ted M. Dawson, Valina L. Dawson, Ruggero De Maria, Bart De Strooper, Klaus Michael Debatin, Ralph J. Deberardinis, Alexei Degterev, Giannino Del Sal, Mohanish Deshmukh, Francesco Di Virgilio, Marc Diederich, Scott J. Dixon, Brian D. Dynlacht, Wafik S. El-Deiry, John W. Elrod, Kurt Engeland, Gian Maria Fimia, Claudia Galassi, Carlo Ganini, Ana J. Garcia-Saez, Abhishek D. Garg, Carmen Garrido, Evripidis Gavathiotis, Motti Gerlic, Sourav Ghosh, Douglas R. Green, Lloyd A. Greene, Hinrich Gronemeyer, Georg Häcker, György Hajnóczky, J. Marie Hardwick, Ygal Haupt, Sudan He, David M. Heery, Michael O. Hengartner, Claudio Hetz, David A. Hildeman, Hidenori Ichijo, Satoshi Inoue, Marja Jäättelä, Ana Janic, Bertrand Joseph, Philipp J. Jost, Thirumala Devi Kanneganti, Michael Karin, Hamid Kashkar, Thomas Kaufmann, Gemma L. Kelly, Oliver Kepp, Adi Kimchi, Richard N. Kitsis, Daniel J. Klionsky, Ruth Kluck, Dmitri V. Krysko, Dagmar Kulms, Sharad Kumar, Sergio Lavandero, Inna N. Lavrik, John J. Lemasters, Gianmaria Liccardi, Andreas Linkermann, Stuart A. Lipton, Richard A. Lockshin, Carlos López-Otín, Tom Luedde, Marion MacFarlane, Frank Madeo, Walter Malorni, Gwenola Manic, Roberto Mantovani, Saverio Marchi, Jean Christophe Marine, Seamus J. Martin, Jean Claude Martinou, Pier G. Mastroberardino, Jan Paul Medema, Patrick Mehlen, Pascal Meier, Gerry Melino, Sonia Melino, Edward A. Miao, Ute M. Moll, Cristina Muñoz-Pinedo, Daniel J. Murphy, Maria Victoria Niklison-Chirou, Flavia Novelli, Gabriel Núñez, Andrew Oberst, Dimitry Ofengeim, Joseph T. Opferman, Moshe Oren, Michele Pagano, Theocharis Panaretakis, Manolis Pasparakis, Josef M. Penninger, Francesca Pentimalli, David M. Pereira, Shazib Pervaiz, Marcus E. Peter, Paolo Pinton, Giovanni Porta, Jochen H.M. Prehn, Hamsa Puthalakath, Gabriel A. Rabinovich, Krishnaraj Rajalingam, Kodi S. Ravichandran, Markus Rehm, Jean Ehrland Ricci, Rosario Rizzuto, Nirmal Robinson, Cecilia M.P. Rodrigues, Barak Rotblat, Carla V. Rothlin, David C. Rubinsztein, Thomas Rudel, Alessandro Rufini, Kevin M. Ryan, Kristopher A. Sarosiek, Akira Sawa, Emre Sayan, Kate Schroder, Luca Scorrano, Federico Sesti, Feng Shao, Yufang Shi, Giuseppe S. Sica, John Silke, Hans Uwe Simon, Antonella Sistigu, Anastasis Stephanou, Brent R. Stockwell, Flavie Strapazzon, Andreas Strasser, Liming Sun, Erwei Sun, Qiang Sun, Gyorgy Szabadkai, Stephen W.G. Tait, Daolin Tang, Nektarios Tavernarakis, Carol M. Troy, Boris Turk, Nicoletta Urbano, Peter Vandenabeele, Tom Vanden Berghe, Matthew G. Vander Heiden, Jacqueline L. Vanderluit, Alexei Verkhratsky, Andreas Villunger, Silvia von Karstedt, Anne K. Voss, Karen H. Vousden, Domagoj Vucic, Daniela Vuri, Erwin F. Wagner, Henning Walczak, David Wallach, Ruoning Wang, Ying Wang, Achim Weber, Will Wood, Takahiro Yamazaki, Huang Tian Yang, Zahra Zakeri, Joanna E. Zawacka-Pankau, Lin Zhang, Haibing Zhang, Boris Zhivotovsky, Wenzhao Zhou, Mauro Piacentini, Guido Kroemer, Lorenzo Galluzzi

Research output: Contribution to journal › Review article › peer-review

69 Scopus citations

Abstract

Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease.

Original language	English (US)
Pages (from-to)	1097-1154
Number of pages	58
Journal	Cell Death and Differentiation
Volume	30
Issue number	5
DOIs	https://doi.org/10.1038/s41418-023-01153-w
State	Published - May 2023

ASJC Scopus subject areas

Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/s41418-023-01153-w

Cite this

Vitale, I., Pietrocola, F., Guilbaud, E., Aaronson, S. A., Abrams, J. M., Adam, D., Agostini, M., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., Aqeilan, R. I., Arama, E., Baehrecke, E. H., Balachandran, S., Bano, D., Barlev, N. A., Bartek, J., ... Galluzzi, L. (2023). Apoptotic cell death in disease—Current understanding of the NCCD 2023. Cell Death and Differentiation, 30(5), 1097-1154. https://doi.org/10.1038/s41418-023-01153-w

Vitale, I, Pietrocola, F, Guilbaud, E, Aaronson, SA, Abrams, JM, Adam, D, Agostini, M, Agostinis, P, Alnemri, ES, Altucci, L, Amelio, I, Andrews, DW, Aqeilan, RI, Arama, E, Baehrecke, EH, Balachandran, S, Bano, D, Barlev, NA, Bartek, J, Bazan, NG, Becker, C, Bernassola, F, Bertrand, MJM, Bianchi, ME, Blagosklonny, MV, Blander, JM, Blandino, G, Blomgren, K, Borner, C, Bortner, CD, Bove, P, Boya, P, Brenner, C, Broz, P, Brunner, T, Damgaard, RB, Calin, GA, Campanella, M, Candi, E, Carbone, M, Carmona-Gutierrez, D, Cecconi, F, Chan, FKM, Chen, GQ, Chen, Q, Chen, YH, Cheng, EH, Chipuk, JE, Cidlowski, JA, Ciechanover, A, Ciliberto, G, Conrad, M, Cubillos-Ruiz, JR, Czabotar, PE, D’Angiolella, V, Daugaard, M, Dawson, TM, Dawson, VL, De Maria, R, De Strooper, B, Debatin, KM, Deberardinis, RJ, Degterev, A, Del Sal, G, Deshmukh, M, Di Virgilio, F, Diederich, M, Dixon, SJ, Dynlacht, BD, El-Deiry, WS, Elrod, JW, Engeland, K, Fimia, GM, Galassi, C, Ganini, C, Garcia-Saez, AJ, Garg, AD, Garrido, C, Gavathiotis, E, Gerlic, M, Ghosh, S, Green, DR, Greene, LA, Gronemeyer, H, Häcker, G, Hajnóczky, G, Hardwick, JM, Haupt, Y, He, S, Heery, DM, Hengartner, MO, Hetz, C, Hildeman, DA, Ichijo, H, Inoue, S, Jäättelä, M, Janic, A, Joseph, B, Jost, PJ, Kanneganti, TD, Karin, M, Kashkar, H, Kaufmann, T, Kelly, GL, Kepp, O, Kimchi, A, Kitsis, RN, Klionsky, DJ, Kluck, R, Krysko, DV, Kulms, D, Kumar, S, Lavandero, S, Lavrik, IN, Lemasters, JJ, Liccardi, G, Linkermann, A, Lipton, SA, Lockshin, RA, López-Otín, C, Luedde, T, MacFarlane, M, Madeo, F, Malorni, W, Manic, G, Mantovani, R, Marchi, S, Marine, JC, Martin, SJ, Martinou, JC, Mastroberardino, PG, Medema, JP, Mehlen, P, Meier, P, Melino, G, Melino, S, Miao, EA, Moll, UM, Muñoz-Pinedo, C, Murphy, DJ, Niklison-Chirou, MV, Novelli, F, Núñez, G, Oberst, A, Ofengeim, D, Opferman, JT, Oren, M, Pagano, M, Panaretakis, T, Pasparakis, M, Penninger, JM, Pentimalli, F, Pereira, DM, Pervaiz, S, Peter, ME, Pinton, P, Porta, G, Prehn, JHM, Puthalakath, H, Rabinovich, GA, Rajalingam, K, Ravichandran, KS, Rehm, M, Ricci, JE, Rizzuto, R, Robinson, N, Rodrigues, CMP, Rotblat, B, Rothlin, CV, Rubinsztein, DC, Rudel, T, Rufini, A, Ryan, KM, Sarosiek, KA, Sawa, A, Sayan, E, Schroder, K, Scorrano, L, Sesti, F, Shao, F, Shi, Y, Sica, GS, Silke, J, Simon, HU, Sistigu, A, Stephanou, A, Stockwell, BR, Strapazzon, F, Strasser, A, Sun, L, Sun, E, Sun, Q, Szabadkai, G, Tait, SWG, Tang, D, Tavernarakis, N, Troy, CM, Turk, B, Urbano, N, Vandenabeele, P, Vanden Berghe, T, Vander Heiden, MG, Vanderluit, JL, Verkhratsky, A, Villunger, A, von Karstedt, S, Voss, AK, Vousden, KH, Vucic, D, Vuri, D, Wagner, EF, Walczak, H, Wallach, D, Wang, R, Wang, Y, Weber, A, Wood, W, Yamazaki, T, Yang, HT, Zakeri, Z, Zawacka-Pankau, JE, Zhang, L, Zhang, H, Zhivotovsky, B, Zhou, W, Piacentini, M, Kroemer, G & Galluzzi, L 2023, 'Apoptotic cell death in disease—Current understanding of the NCCD 2023', Cell Death and Differentiation, vol. 30, no. 5, pp. 1097-1154. https://doi.org/10.1038/s41418-023-01153-w

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title = "Apoptotic cell death in disease—Current understanding of the NCCD 2023",

abstract = "Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease.",

author = "Ilio Vitale and Federico Pietrocola and Emma Guilbaud and Aaronson, {Stuart A.} and Abrams, {John M.} and Dieter Adam and Massimiliano Agostini and Patrizia Agostinis and Alnemri, {Emad S.} and Lucia Altucci and Ivano Amelio and Andrews, {David W.} and Aqeilan, {Rami I.} and Eli Arama and Baehrecke, {Eric H.} and Siddharth Balachandran and Daniele Bano and Barlev, {Nickolai A.} and Jiri Bartek and Bazan, {Nicolas G.} and Christoph Becker and Francesca Bernassola and Bertrand, {Mathieu J.M.} and Bianchi, {Marco E.} and Blagosklonny, {Mikhail V.} and Blander, {J. Magarian} and Giovanni Blandino and Klas Blomgren and Christoph Borner and Bortner, {Carl D.} and Pierluigi Bove and Patricia Boya and Catherine Brenner and Petr Broz and Thomas Brunner and Damgaard, {Rune Busk} and Calin, {George A.} and Michelangelo Campanella and Eleonora Candi and Michele Carbone and Didac Carmona-Gutierrez and Francesco Cecconi and Chan, {Francis K.M.} and Chen, {Guo Qiang} and Quan Chen and Chen, {Youhai H.} and Cheng, {Emily H.} and Chipuk, {Jerry E.} and Cidlowski, {John A.} and Aaron Ciechanover and Gennaro Ciliberto and Marcus Conrad and Cubillos-Ruiz, {Juan R.} and Czabotar, {Peter E.} and Vincenzo D{\textquoteright}Angiolella and Mads Daugaard and Dawson, {Ted M.} and Dawson, {Valina L.} and {De Maria}, Ruggero and {De Strooper}, Bart and Debatin, {Klaus Michael} and Deberardinis, {Ralph J.} and Alexei Degterev and {Del Sal}, Giannino and Mohanish Deshmukh and {Di Virgilio}, Francesco and Marc Diederich and Dixon, {Scott J.} and Dynlacht, {Brian D.} and El-Deiry, {Wafik S.} and Elrod, {John W.} and Kurt Engeland and Fimia, {Gian Maria} and Claudia Galassi and Carlo Ganini and Garcia-Saez, {Ana J.} and Garg, {Abhishek D.} and Carmen Garrido and Evripidis Gavathiotis and Motti Gerlic and Sourav Ghosh and Green, {Douglas R.} and Greene, {Lloyd A.} and Hinrich Gronemeyer and Georg H{\"a}cker and Gy{\"o}rgy Hajn{\'o}czky and Hardwick, {J. Marie} and Ygal Haupt and Sudan He and Heery, {David M.} and Hengartner, {Michael O.} and Claudio Hetz and Hildeman, {David A.} and Hidenori Ichijo and Satoshi Inoue and Marja J{\"a}{\"a}ttel{\"a} and Ana Janic and Bertrand Joseph and Jost, {Philipp J.} and Kanneganti, {Thirumala Devi} and Michael Karin and Hamid Kashkar and Thomas Kaufmann and Kelly, {Gemma L.} and Oliver Kepp and Adi Kimchi and Kitsis, {Richard N.} and Klionsky, {Daniel J.} and Ruth Kluck and Krysko, {Dmitri V.} and Dagmar Kulms and Sharad Kumar and Sergio Lavandero and Lavrik, {Inna N.} and Lemasters, {John J.} and Gianmaria Liccardi and Andreas Linkermann and Lipton, {Stuart A.} and Lockshin, {Richard A.} and Carlos L{\'o}pez-Ot{\'i}n and Tom Luedde and Marion MacFarlane and Frank Madeo and Walter Malorni and Gwenola Manic and Roberto Mantovani and Saverio Marchi and Marine, {Jean Christophe} and Martin, {Seamus J.} and Martinou, {Jean Claude} and Mastroberardino, {Pier G.} and Medema, {Jan Paul} and Patrick Mehlen and Pascal Meier and Gerry Melino and Sonia Melino and Miao, {Edward A.} and Moll, {Ute M.} and Cristina Mu{\~n}oz-Pinedo and Murphy, {Daniel J.} and Niklison-Chirou, {Maria Victoria} and Flavia Novelli and Gabriel N{\'u}{\~n}ez and Andrew Oberst and Dimitry Ofengeim and Opferman, {Joseph T.} and Moshe Oren and Michele Pagano and Theocharis Panaretakis and Manolis Pasparakis and Penninger, {Josef M.} and Francesca Pentimalli and Pereira, {David M.} and Shazib Pervaiz and Peter, {Marcus E.} and Paolo Pinton and Giovanni Porta and Prehn, {Jochen H.M.} and Hamsa Puthalakath and Rabinovich, {Gabriel A.} and Krishnaraj Rajalingam and Ravichandran, {Kodi S.} and Markus Rehm and Ricci, {Jean Ehrland} and Rosario Rizzuto and Nirmal Robinson and Rodrigues, {Cecilia M.P.} and Barak Rotblat and Rothlin, {Carla V.} and Rubinsztein, {David C.} and Thomas Rudel and Alessandro Rufini and Ryan, {Kevin M.} and Sarosiek, {Kristopher A.} and Akira Sawa and Emre Sayan and Kate Schroder and Luca Scorrano and Federico Sesti and Feng Shao and Yufang Shi and Sica, {Giuseppe S.} and John Silke and Simon, {Hans Uwe} and Antonella Sistigu and Anastasis Stephanou and Stockwell, {Brent R.} and Flavie Strapazzon and Andreas Strasser and Liming Sun and Erwei Sun and Qiang Sun and Gyorgy Szabadkai and Tait, {Stephen W.G.} and Daolin Tang and Nektarios Tavernarakis and Troy, {Carol M.} and Boris Turk and Nicoletta Urbano and Peter Vandenabeele and {Vanden Berghe}, Tom and {Vander Heiden}, {Matthew G.} and Vanderluit, {Jacqueline L.} and Alexei Verkhratsky and Andreas Villunger and {von Karstedt}, Silvia and Voss, {Anne K.} and Vousden, {Karen H.} and Domagoj Vucic and Daniela Vuri and Wagner, {Erwin F.} and Henning Walczak and David Wallach and Ruoning Wang and Ying Wang and Achim Weber and Will Wood and Takahiro Yamazaki and Yang, {Huang Tian} and Zahra Zakeri and Zawacka-Pankau, {Joanna E.} and Lin Zhang and Haibing Zhang and Boris Zhivotovsky and Wenzhao Zhou and Mauro Piacentini and Guido Kroemer and Lorenzo Galluzzi",

note = "Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare.",

year = "2023",

month = may,

doi = "10.1038/s41418-023-01153-w",

language = "English (US)",

volume = "30",

pages = "1097--1154",

journal = "Cell Death and Differentiation",

issn = "1350-9047",

publisher = "Nature Publishing Group",

number = "5",

}

TY - JOUR

T1 - Apoptotic cell death in disease—Current understanding of the NCCD 2023

AU - Vitale, Ilio

AU - Pietrocola, Federico

AU - Guilbaud, Emma

AU - Aaronson, Stuart A.

AU - Abrams, John M.

AU - Adam, Dieter

AU - Agostini, Massimiliano

AU - Agostinis, Patrizia

AU - Alnemri, Emad S.

AU - Altucci, Lucia

AU - Amelio, Ivano

AU - Andrews, David W.

AU - Aqeilan, Rami I.

AU - Arama, Eli

AU - Baehrecke, Eric H.

AU - Balachandran, Siddharth

AU - Bano, Daniele

AU - Barlev, Nickolai A.

AU - Bartek, Jiri

AU - Bazan, Nicolas G.

AU - Becker, Christoph

AU - Bernassola, Francesca

AU - Bertrand, Mathieu J.M.

AU - Bianchi, Marco E.

AU - Blagosklonny, Mikhail V.

AU - Blander, J. Magarian

AU - Blandino, Giovanni

AU - Blomgren, Klas

AU - Borner, Christoph

AU - Bortner, Carl D.

AU - Bove, Pierluigi

AU - Boya, Patricia

AU - Brenner, Catherine

AU - Broz, Petr

AU - Brunner, Thomas

AU - Damgaard, Rune Busk

AU - Calin, George A.

AU - Campanella, Michelangelo

AU - Candi, Eleonora

AU - Carbone, Michele

AU - Carmona-Gutierrez, Didac

AU - Cecconi, Francesco

AU - Chan, Francis K.M.

AU - Chen, Guo Qiang

AU - Chen, Quan

AU - Chen, Youhai H.

AU - Cheng, Emily H.

AU - Chipuk, Jerry E.

AU - Cidlowski, John A.

AU - Ciechanover, Aaron

AU - Ciliberto, Gennaro

AU - Conrad, Marcus

AU - Cubillos-Ruiz, Juan R.

AU - Czabotar, Peter E.

AU - D’Angiolella, Vincenzo

AU - Daugaard, Mads

AU - Dawson, Ted M.

AU - Dawson, Valina L.

AU - De Maria, Ruggero

AU - De Strooper, Bart

AU - Debatin, Klaus Michael

AU - Deberardinis, Ralph J.

AU - Degterev, Alexei

AU - Del Sal, Giannino

AU - Deshmukh, Mohanish

AU - Di Virgilio, Francesco

AU - Diederich, Marc

AU - Dixon, Scott J.

AU - Dynlacht, Brian D.

AU - El-Deiry, Wafik S.

AU - Elrod, John W.

AU - Engeland, Kurt

AU - Fimia, Gian Maria

AU - Galassi, Claudia

AU - Ganini, Carlo

AU - Garcia-Saez, Ana J.

AU - Garg, Abhishek D.

AU - Garrido, Carmen

AU - Gavathiotis, Evripidis

AU - Gerlic, Motti

AU - Ghosh, Sourav

AU - Green, Douglas R.

AU - Greene, Lloyd A.

AU - Gronemeyer, Hinrich

AU - Häcker, Georg

AU - Hajnóczky, György

AU - Hardwick, J. Marie

AU - Haupt, Ygal

AU - He, Sudan

AU - Heery, David M.

AU - Hengartner, Michael O.

AU - Hetz, Claudio

AU - Hildeman, David A.

AU - Ichijo, Hidenori

AU - Inoue, Satoshi

AU - Jäättelä, Marja

AU - Janic, Ana

AU - Joseph, Bertrand

AU - Jost, Philipp J.

AU - Kanneganti, Thirumala Devi

AU - Karin, Michael

AU - Kashkar, Hamid

AU - Kaufmann, Thomas

AU - Kelly, Gemma L.

AU - Kepp, Oliver

AU - Kimchi, Adi

AU - Kitsis, Richard N.

AU - Klionsky, Daniel J.

AU - Kluck, Ruth

AU - Krysko, Dmitri V.

AU - Kulms, Dagmar

AU - Kumar, Sharad

AU - Lavandero, Sergio

AU - Lavrik, Inna N.

AU - Lemasters, John J.

AU - Liccardi, Gianmaria

AU - Linkermann, Andreas

AU - Lipton, Stuart A.

AU - Lockshin, Richard A.

AU - López-Otín, Carlos

AU - Luedde, Tom

AU - MacFarlane, Marion

AU - Madeo, Frank

AU - Malorni, Walter

AU - Manic, Gwenola

AU - Mantovani, Roberto

AU - Marchi, Saverio

AU - Marine, Jean Christophe

AU - Martin, Seamus J.

AU - Martinou, Jean Claude

AU - Mastroberardino, Pier G.

AU - Medema, Jan Paul

AU - Mehlen, Patrick

AU - Meier, Pascal

AU - Melino, Gerry

AU - Melino, Sonia

AU - Miao, Edward A.

AU - Moll, Ute M.

AU - Muñoz-Pinedo, Cristina

AU - Murphy, Daniel J.

AU - Niklison-Chirou, Maria Victoria

AU - Novelli, Flavia

AU - Núñez, Gabriel

AU - Oberst, Andrew

AU - Ofengeim, Dimitry

AU - Opferman, Joseph T.

AU - Oren, Moshe

AU - Pagano, Michele

AU - Panaretakis, Theocharis

AU - Pasparakis, Manolis

AU - Penninger, Josef M.

AU - Pentimalli, Francesca

AU - Pereira, David M.

AU - Pervaiz, Shazib

AU - Peter, Marcus E.

AU - Pinton, Paolo

AU - Porta, Giovanni

AU - Prehn, Jochen H.M.

AU - Puthalakath, Hamsa

AU - Rabinovich, Gabriel A.

AU - Rajalingam, Krishnaraj

AU - Ravichandran, Kodi S.

AU - Rehm, Markus

AU - Ricci, Jean Ehrland

AU - Rizzuto, Rosario

AU - Robinson, Nirmal

AU - Rodrigues, Cecilia M.P.

AU - Rotblat, Barak

AU - Rothlin, Carla V.

AU - Rubinsztein, David C.

AU - Rudel, Thomas

AU - Rufini, Alessandro

AU - Ryan, Kevin M.

AU - Sarosiek, Kristopher A.

AU - Sawa, Akira

AU - Sayan, Emre

AU - Schroder, Kate

AU - Scorrano, Luca

AU - Sesti, Federico

AU - Shao, Feng

AU - Shi, Yufang

AU - Sica, Giuseppe S.

AU - Silke, John

AU - Simon, Hans Uwe

AU - Sistigu, Antonella

AU - Stephanou, Anastasis

AU - Stockwell, Brent R.

AU - Strapazzon, Flavie

AU - Strasser, Andreas

AU - Sun, Liming

AU - Sun, Erwei

AU - Sun, Qiang

AU - Szabadkai, Gyorgy

AU - Tait, Stephen W.G.

AU - Tang, Daolin

AU - Tavernarakis, Nektarios

AU - Troy, Carol M.

AU - Turk, Boris

AU - Urbano, Nicoletta

AU - Vandenabeele, Peter

AU - Vanden Berghe, Tom

AU - Vander Heiden, Matthew G.

AU - Vanderluit, Jacqueline L.

AU - Verkhratsky, Alexei

AU - Villunger, Andreas

AU - von Karstedt, Silvia

AU - Voss, Anne K.

AU - Vousden, Karen H.

AU - Vucic, Domagoj

AU - Vuri, Daniela

AU - Wagner, Erwin F.

AU - Walczak, Henning

AU - Wallach, David

AU - Wang, Ruoning

AU - Wang, Ying

AU - Weber, Achim

AU - Wood, Will

AU - Yamazaki, Takahiro

AU - Yang, Huang Tian

AU - Zakeri, Zahra

AU - Zawacka-Pankau, Joanna E.

AU - Zhang, Lin

AU - Zhang, Haibing

AU - Zhivotovsky, Boris

AU - Zhou, Wenzhao

AU - Piacentini, Mauro

AU - Kroemer, Guido

AU - Galluzzi, Lorenzo

PY - 2023/5

Y1 - 2023/5

N2 - Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease.

AB - Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease.

UR - http://www.scopus.com/inward/record.url?scp=85153609153&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85153609153&partnerID=8YFLogxK

U2 - 10.1038/s41418-023-01153-w

DO - 10.1038/s41418-023-01153-w

M3 - Review article

C2 - 37100955

AN - SCOPUS:85153609153

SN - 1350-9047

VL - 30

SP - 1097

EP - 1154

JO - Cell Death and Differentiation

JF - Cell Death and Differentiation

IS - 5

ER -

Apoptotic cell death in disease—Current understanding of the NCCD 2023

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