TY - JOUR
T1 - Antimetastatic Effects of Curcumin in Oral and Gastrointestinal Cancers
AU - Davoodvandi, Amirhossein
AU - Farshadi, Marjan
AU - Zare, Noushid
AU - Akhlagh, Seyed Amirreza
AU - Alipour Nosrani, Esmail
AU - Mahjoubin-Tehran, Maryam
AU - Kangari, Parisa
AU - Sharafi, Seyedeh Maryam
AU - Khan, Haroon
AU - Aschner, Michael
AU - Baniebrahimi, Ghazaleh
AU - Mirzaei, Hamed
N1 - Funding Information:
MA was supported in part by the National Institute of Environmental Health Sciences (NIEHS) R01ES07331.
Publisher Copyright:
© Copyright © 2021 Davoodvandi, Farshadi, Zare, Akhlagh, Alipour Nosrani, Mahjoubin-Tehran, Kangari, Sharafi, Khan, Aschner, Baniebrahimi and Mirzaei.
PY - 2021/8/11
Y1 - 2021/8/11
N2 - Gastrointestinal (GI) cancers are known as frequently occurred solid malignant tumors that can cause the high rate mortality in the world. Metastasis is a significant destructive feature of tumoral cells, which directly correlates with decreased prognosis and survival. Curcumin, which is found in turmeric, has been identified as a potent therapeutic natural bioactive compound (Curcuma longa). It has been traditionally applied for centuries to treat different diseases, and it has shown efficacy for its anticancer properties. Numerous studies have revealed that curcumin inhibits migration and metastasis of GI cancer cells by modulating various genes and proteins, i.e., growth factors, inflammatory cytokines and their receptors, different types of enzymes, caspases, cell adhesion molecules, and cell cycle proteins. Herein, we summarized the antimetastatic effects of curcumin in GI cancers, including pancreatic cancer, gastric cancer, colorectal cancer, oral cancer, and esophageal cancer.
AB - Gastrointestinal (GI) cancers are known as frequently occurred solid malignant tumors that can cause the high rate mortality in the world. Metastasis is a significant destructive feature of tumoral cells, which directly correlates with decreased prognosis and survival. Curcumin, which is found in turmeric, has been identified as a potent therapeutic natural bioactive compound (Curcuma longa). It has been traditionally applied for centuries to treat different diseases, and it has shown efficacy for its anticancer properties. Numerous studies have revealed that curcumin inhibits migration and metastasis of GI cancer cells by modulating various genes and proteins, i.e., growth factors, inflammatory cytokines and their receptors, different types of enzymes, caspases, cell adhesion molecules, and cell cycle proteins. Herein, we summarized the antimetastatic effects of curcumin in GI cancers, including pancreatic cancer, gastric cancer, colorectal cancer, oral cancer, and esophageal cancer.
KW - curcumin
KW - gastric cancer
KW - gastrointestinal cancer (GI cancer)
KW - metastasis
KW - therapy
UR - http://www.scopus.com/inward/record.url?scp=85113481128&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85113481128&partnerID=8YFLogxK
U2 - 10.3389/fphar.2021.668567
DO - 10.3389/fphar.2021.668567
M3 - Review article
AN - SCOPUS:85113481128
SN - 1663-9812
VL - 12
JO - Frontiers in Pharmacology
JF - Frontiers in Pharmacology
M1 - 668567
ER -
