Anthrax-associated shock

David L. Goldman, Arturo Casadevall

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Recent events have brought attention to the potential of Bacillus anthracis as an agent of bioterrorism. The shock like state of anthrax is invariably associated with high mortality, despite anti-microbial and supportive therapy. Multi-system dysfunction is typical, including: enhanced vascular permeability, hemorrhage and inflammation. Important questions concerning the pathophysiology of anthrax-associated shock remain unanswered, including the effects of B. anthracis infection on cardiac function. This review discusses the current state of knowledge regarding the pathophysiology of anthrax-associated shock.

Original languageEnglish (US)
Pages (from-to)4009-4014
Number of pages6
JournalFrontiers in Bioscience
Issue number11
StatePublished - 2008


  • Anthrax
  • Bacillus anthracis
  • Edema toxin
  • Lethal toxin
  • Review
  • Shock

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology


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