TY - JOUR
T1 - Animal Models and Childhood Behavioral Disturbances
T2 - Dopamine Depletion in the Newborn Rat Pup
AU - Alpert, Jonathan E.
AU - Cohen, Donald J.
AU - Shaywitz, Bennett A.
AU - Piccirillo, Mark
AU - Shaywitz, Sally E.
N1 - Funding Information:
Mr. Alp& is Graduate Research Associate and Dr. Cohen is Associate Professor of PediaEncs, Psychiatry, and Psychology, Yale University Child Study Center. Lk. Bennett Shuywitz is Associate Profes- sor of Pediatrics and Neurology, Mr. Piccirillo is a medical student, and Lk. Sally Shaywitz is Assistant Clinical Professor of Pediatrics, all at Yale University School of Medicine. This research was supported in part by Public Health Smice Research Grants HD-03008 and NS- 12384, The Charles Hood Foundation, The Nutrition Foundation, and Mr. Leonard Berger. Reprints may be requested from Dr. Cohen at the Yale Child Study Center, 33? Cedar Street, New Haven, CT 0651 0.
PY - 1978
Y1 - 1978
N2 - Abnormalities in catecholamine metabolism have been implicated in the pathogenesis of various psychiatric disturbances of childhood, including minimal brain or cerebral dysfunction (MBD), childhood psychosis, affective disturbances, and the syndrome of chronic multiple tics. Developmental research on the relationship between brain function and behavior can be facilitated by appropriate animal models, interpreted conservatively. When rat pups are selectively depleted of brain dopamine by treatment with 6-hydroxydopamine in the newborn period, they display a constellation of behaviors similar to those seen in childhood MBD: hyperactivity, disturbed habituation, cognitive deficits, and “normalization” with stimulant medication. As adults, dopamine-depleted rats exhibit aberrations in mothering. This and similar models may help clarify certain aspects of the developmental associations between alterations in brain physiology, abnormal psychological mechanisms, and the emergence of behavioral deviance.
AB - Abnormalities in catecholamine metabolism have been implicated in the pathogenesis of various psychiatric disturbances of childhood, including minimal brain or cerebral dysfunction (MBD), childhood psychosis, affective disturbances, and the syndrome of chronic multiple tics. Developmental research on the relationship between brain function and behavior can be facilitated by appropriate animal models, interpreted conservatively. When rat pups are selectively depleted of brain dopamine by treatment with 6-hydroxydopamine in the newborn period, they display a constellation of behaviors similar to those seen in childhood MBD: hyperactivity, disturbed habituation, cognitive deficits, and “normalization” with stimulant medication. As adults, dopamine-depleted rats exhibit aberrations in mothering. This and similar models may help clarify certain aspects of the developmental associations between alterations in brain physiology, abnormal psychological mechanisms, and the emergence of behavioral deviance.
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U2 - 10.1016/S0002-7138(10)60089-1
DO - 10.1016/S0002-7138(10)60089-1
M3 - Article
C2 - 659743
AN - SCOPUS:0018249714
SN - 0002-7138
VL - 17
SP - 239
EP - 251
JO - Journal of the American Academy of Child Psychiatry
JF - Journal of the American Academy of Child Psychiatry
IS - 2
ER -
