Analysis of the specific pathways and networks of prostate cancer for gene expression profiles in the Chinese population

Jia Hong Chen; Hui Chan He; Fu Neng Jiang; Julia Militar; Petor Yang Ran; Guo Qiang Qin; Chao Cai; Xi Bin Chen; Jin Zhao; Zi Yao Mo; Yan Ru Chen; Jian Guo Zhu; Xingyin Liu; Wei De Zhong

doi:10.1007/s12032-011-0088-5

Analysis of the specific pathways and networks of prostate cancer for gene expression profiles in the Chinese population

Jia Hong Chen, Hui Chan He, Fu Neng Jiang, Julia Militar, Petor Yang Ran, Guo Qiang Qin, Chao Cai, Xi Bin Chen, Jin Zhao, Zi Yao Mo, Yan Ru Chen, Jian Guo Zhu, Xingyin Liu, Wei De Zhong

Genetics

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The global physiological function of specifically expressed genes of prostate cancer in Chinese patients is unclear. This study aims to determine the genome-wide expression of genes related to prostate cancer in the Chinese population. Genes that were differentially expressed in prostate cancer were identified using DNA microarray technology. Expressions were validated by using real-time PCR. The identified genes were analyzed using the ingenuity pathway analysis (IPA) to investigate the gene ontology, functional pathway and network. A total of 1,444 genes (Fold time ≥ 1.5; P ≥ 0.05) were differentially expressed in prostate primary tumor tissue compared with benign tissue. IPA revealed a unique landscape where inductions of certain pathways were involved in Cell Cycle Regulation and proliferation. Network analysis not only confirmed that protein interactions lead to the deregulation of DNA Replication, Recombination and Repair, Cellular Compromise and Cell Cycle, Genetic Disorders and Connective Tissue Disorders, but it was also observed that many of the genes regulated by Myc contributed to the modulation of lipid Metabolism and Nucleic Acid Metabolism. Both pathway and network analysis exhibited some remarkable characteristics of prostate cancer for Chinese patients, which showed profound differences from that of other non-Chinese populations. These differences may provide new insights into the molecular cascade of prostate cancer that occurs in Chinese patients.

Original language	English (US)
Pages (from-to)	1972-1984
Number of pages	13
Journal	Medical Oncology
Volume	29
Issue number	3
DOIs	https://doi.org/10.1007/s12032-011-0088-5
State	Published - Sep 2012

Keywords

Gene expression profile
Gene network
Global pathway analysis
Prostate cancer

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12032-011-0088-5

Cite this

Chen, J. H., He, H. C., Jiang, F. N., Militar, J., Ran, P. Y., Qin, G. Q., Cai, C., Chen, X. B., Zhao, J., Mo, Z. Y., Chen, Y. R., Zhu, J. G., Liu, X., & Zhong, W. D. (2012). Analysis of the specific pathways and networks of prostate cancer for gene expression profiles in the Chinese population. Medical Oncology, 29(3), 1972-1984. https://doi.org/10.1007/s12032-011-0088-5

@article{b4485684fbc14b8caf840f09a017b8ef,

title = "Analysis of the specific pathways and networks of prostate cancer for gene expression profiles in the Chinese population",

abstract = "The global physiological function of specifically expressed genes of prostate cancer in Chinese patients is unclear. This study aims to determine the genome-wide expression of genes related to prostate cancer in the Chinese population. Genes that were differentially expressed in prostate cancer were identified using DNA microarray technology. Expressions were validated by using real-time PCR. The identified genes were analyzed using the ingenuity pathway analysis (IPA) to investigate the gene ontology, functional pathway and network. A total of 1,444 genes (Fold time ≥ 1.5; P ≥ 0.05) were differentially expressed in prostate primary tumor tissue compared with benign tissue. IPA revealed a unique landscape where inductions of certain pathways were involved in Cell Cycle Regulation and proliferation. Network analysis not only confirmed that protein interactions lead to the deregulation of DNA Replication, Recombination and Repair, Cellular Compromise and Cell Cycle, Genetic Disorders and Connective Tissue Disorders, but it was also observed that many of the genes regulated by Myc contributed to the modulation of lipid Metabolism and Nucleic Acid Metabolism. Both pathway and network analysis exhibited some remarkable characteristics of prostate cancer for Chinese patients, which showed profound differences from that of other non-Chinese populations. These differences may provide new insights into the molecular cascade of prostate cancer that occurs in Chinese patients.",

keywords = "Gene expression profile, Gene network, Global pathway analysis, Prostate cancer",

author = "Chen, {Jia Hong} and He, {Hui Chan} and Jiang, {Fu Neng} and Julia Militar and Ran, {Petor Yang} and Qin, {Guo Qiang} and Chao Cai and Chen, {Xi Bin} and Jin Zhao and Mo, {Zi Yao} and Chen, {Yan Ru} and Zhu, {Jian Guo} and Xingyin Liu and Zhong, {Wei De}",

note = "Funding Information: Acknowledgments This work was supported by grants from the Natural Science Foundation of Guangdong Province (04003650), National Natural Science Foundation of China (30872960), Key projects of Bureau of Health in Guangzhou Municipality (201102A212015) and projects of Guangdong Key Laboratory of Urology (2010A060801016).",

year = "2012",

month = sep,

doi = "10.1007/s12032-011-0088-5",

language = "English (US)",

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T1 - Analysis of the specific pathways and networks of prostate cancer for gene expression profiles in the Chinese population

AU - Chen, Jia Hong

AU - He, Hui Chan

AU - Jiang, Fu Neng

AU - Militar, Julia

AU - Ran, Petor Yang

AU - Qin, Guo Qiang

AU - Cai, Chao

AU - Chen, Xi Bin

AU - Zhao, Jin

AU - Mo, Zi Yao

AU - Chen, Yan Ru

AU - Zhu, Jian Guo

AU - Liu, Xingyin

AU - Zhong, Wei De

N1 - Funding Information: Acknowledgments This work was supported by grants from the Natural Science Foundation of Guangdong Province (04003650), National Natural Science Foundation of China (30872960), Key projects of Bureau of Health in Guangzhou Municipality (201102A212015) and projects of Guangdong Key Laboratory of Urology (2010A060801016).

PY - 2012/9

Y1 - 2012/9

N2 - The global physiological function of specifically expressed genes of prostate cancer in Chinese patients is unclear. This study aims to determine the genome-wide expression of genes related to prostate cancer in the Chinese population. Genes that were differentially expressed in prostate cancer were identified using DNA microarray technology. Expressions were validated by using real-time PCR. The identified genes were analyzed using the ingenuity pathway analysis (IPA) to investigate the gene ontology, functional pathway and network. A total of 1,444 genes (Fold time ≥ 1.5; P ≥ 0.05) were differentially expressed in prostate primary tumor tissue compared with benign tissue. IPA revealed a unique landscape where inductions of certain pathways were involved in Cell Cycle Regulation and proliferation. Network analysis not only confirmed that protein interactions lead to the deregulation of DNA Replication, Recombination and Repair, Cellular Compromise and Cell Cycle, Genetic Disorders and Connective Tissue Disorders, but it was also observed that many of the genes regulated by Myc contributed to the modulation of lipid Metabolism and Nucleic Acid Metabolism. Both pathway and network analysis exhibited some remarkable characteristics of prostate cancer for Chinese patients, which showed profound differences from that of other non-Chinese populations. These differences may provide new insights into the molecular cascade of prostate cancer that occurs in Chinese patients.

AB - The global physiological function of specifically expressed genes of prostate cancer in Chinese patients is unclear. This study aims to determine the genome-wide expression of genes related to prostate cancer in the Chinese population. Genes that were differentially expressed in prostate cancer were identified using DNA microarray technology. Expressions were validated by using real-time PCR. The identified genes were analyzed using the ingenuity pathway analysis (IPA) to investigate the gene ontology, functional pathway and network. A total of 1,444 genes (Fold time ≥ 1.5; P ≥ 0.05) were differentially expressed in prostate primary tumor tissue compared with benign tissue. IPA revealed a unique landscape where inductions of certain pathways were involved in Cell Cycle Regulation and proliferation. Network analysis not only confirmed that protein interactions lead to the deregulation of DNA Replication, Recombination and Repair, Cellular Compromise and Cell Cycle, Genetic Disorders and Connective Tissue Disorders, but it was also observed that many of the genes regulated by Myc contributed to the modulation of lipid Metabolism and Nucleic Acid Metabolism. Both pathway and network analysis exhibited some remarkable characteristics of prostate cancer for Chinese patients, which showed profound differences from that of other non-Chinese populations. These differences may provide new insights into the molecular cascade of prostate cancer that occurs in Chinese patients.

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KW - Gene network

KW - Global pathway analysis

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ER -

Analysis of the specific pathways and networks of prostate cancer for gene expression profiles in the Chinese population

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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