Abstract
To investigate the role of insulin-like growth factor-1 (IGF-1), in localized osteosarcoma, serum levels of IGF-1, IGFBP-2, and IGFBP-3 were measured in 224 similarly treated, newly diagnosed patients. We demonstrated that younger patients had lower concentrations of IGF-1 and IGFBP-3 compared to older (P<0.001) along with lower IGFBP-3:IGF-1 and IGFBP-2:IGF-1 ratios (P<0.001). IGFBP-2 did not correlate with age (P=0.16), yet IGFBP-2:IGF-1 ratios were higher in the younger population (P<0.001). These findings show that older patients have higher concentrations of free IGF-1. None of IGF-1, IGFBP-2, nor IGFBP-3 concentrations were associated with event-free nor overall survival.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 749-752 |
| Number of pages | 4 |
| Journal | Pediatric Blood and Cancer |
| Volume | 61 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2014 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Cancer biology
- Clinical trials
- Osteosarcoma
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Hematology
- Oncology
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