Analysis of catechol-O-methyltransferase and 5-hydroxytryptamine transporter polymorphisms in patients at risk for suicide

Mark J. Russ; Herbert M. Lachman; Todd Kashdan; Takuya Saito; Senada Bajmakovic-Kacila

doi:10.1016/S0165-1781(00)00128-1

Analysis of catechol-O-methyltransferase and 5-hydroxytryptamine transporter polymorphisms in patients at risk for suicide

Mark J. Russ
, Herbert M. Lachman
, Todd Kashdan
, Takuya Saito
, Senada Bajmakovic-Kacila

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Abstract

Genotype frequencies of functional polymorphisms in the genes encoding the serotonin transporter (5-HTT) and the enzyme catechol-O-methyltransferase (COMT) were not different in 51 suicidal inpatients compared to 51 control subjects. Within the patient group, increased hopelessness and suicide ideation were associated with homozygosity of the 5-HTT high promotor activity allele. (C) 2000 Elsevier Science Ireland Ltd.

Original language	English (US)
Pages (from-to)	73-78
Number of pages	6
Journal	Psychiatry Research
Volume	93
Issue number	1
DOIs	https://doi.org/10.1016/S0165-1781(00)00128-1
State	Published - Feb 14 2000

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Hopelessness
Major depression
Serotonin

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

Access to Document

10.1016/S0165-1781(00)00128-1

Cite this

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title = "Analysis of catechol-O-methyltransferase and 5-hydroxytryptamine transporter polymorphisms in patients at risk for suicide",

abstract = "Genotype frequencies of functional polymorphisms in the genes encoding the serotonin transporter (5-HTT) and the enzyme catechol-O-methyltransferase (COMT) were not different in 51 suicidal inpatients compared to 51 control subjects. Within the patient group, increased hopelessness and suicide ideation were associated with homozygosity of the 5-HTT high promotor activity allele. (C) 2000 Elsevier Science Ireland Ltd.",

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AU - Russ, Mark J.

AU - Lachman, Herbert M.

AU - Kashdan, Todd

AU - Saito, Takuya

AU - Bajmakovic-Kacila, Senada

PY - 2000/2/14

Y1 - 2000/2/14

N2 - Genotype frequencies of functional polymorphisms in the genes encoding the serotonin transporter (5-HTT) and the enzyme catechol-O-methyltransferase (COMT) were not different in 51 suicidal inpatients compared to 51 control subjects. Within the patient group, increased hopelessness and suicide ideation were associated with homozygosity of the 5-HTT high promotor activity allele. (C) 2000 Elsevier Science Ireland Ltd.

AB - Genotype frequencies of functional polymorphisms in the genes encoding the serotonin transporter (5-HTT) and the enzyme catechol-O-methyltransferase (COMT) were not different in 51 suicidal inpatients compared to 51 control subjects. Within the patient group, increased hopelessness and suicide ideation were associated with homozygosity of the 5-HTT high promotor activity allele. (C) 2000 Elsevier Science Ireland Ltd.

KW - Hopelessness

KW - Major depression

KW - Serotonin

UR - https://www.scopus.com/pages/publications/0034056199

UR - https://www.scopus.com/pages/publications/0034056199#tab=citedBy

U2 - 10.1016/S0165-1781(00)00128-1

DO - 10.1016/S0165-1781(00)00128-1

M3 - Article

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SN - 0165-1781

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EP - 78

JO - Psychiatry Research

JF - Psychiatry Research

IS - 1

ER -

Analysis of catechol-O-methyltransferase and 5-hydroxytryptamine transporter polymorphisms in patients at risk for suicide

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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