Analysis of associations between 5-HTT, 5-HTR2A, and GABRA6 gene polymorphisms and health-associated personality traits

M. V. Alfimova; M. V. Monakhov; V. E. Golimbet; G. I. Korovaitseva; G. L. Lyashenko

doi:10.1007/s10517-010-0964-6

Analysis of associations between 5-HTT, 5-HTR2A, and GABRA6 gene polymorphisms and health-associated personality traits

M. V. Alfimova, M. V. Monakhov, V. E. Golimbet, G. I. Korovaitseva, G. L. Lyashenko

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The development of personality traits united by the notion of conscientiousness, should promote, along with reduction of anxiety, the physical and mental health. In order to detect the sources of conscientiousness and neurotism formation, we evaluated associations between polymorphic markers of 5-HTT, 5-HTR2A, and GABRA6 genes and relevant scores of TCI questionnaire in a group of 369 volunteers. Associations of markers VNTR and LPR of 5-HTT gene and marker T1521C of GABRA6 gene with "self-directedness" and the effects of 5-HTR2A gene marker T102C and its interactions with the GABRA6 gene on the "harm avoidance" were detected.

Original language	English (US)
Pages (from-to)	434-436
Number of pages	3
Journal	Bulletin of Experimental Biology and Medicine
Volume	149
Issue number	4
DOIs	https://doi.org/10.1007/s10517-010-0964-6
State	Published - Oct 2010
Externally published	Yes

Keywords

gene
health
personality
serotonin
γ-aminobutyric acid

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10517-010-0964-6

Cite this

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abstract = "The development of personality traits united by the notion of conscientiousness, should promote, along with reduction of anxiety, the physical and mental health. In order to detect the sources of conscientiousness and neurotism formation, we evaluated associations between polymorphic markers of 5-HTT, 5-HTR2A, and GABRA6 genes and relevant scores of TCI questionnaire in a group of 369 volunteers. Associations of markers VNTR and LPR of 5-HTT gene and marker T1521C of GABRA6 gene with {"}self-directedness{"} and the effects of 5-HTR2A gene marker T102C and its interactions with the GABRA6 gene on the {"}harm avoidance{"} were detected.",

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AU - Alfimova, M. V.

AU - Monakhov, M. V.

AU - Golimbet, V. E.

AU - Korovaitseva, G. I.

AU - Lyashenko, G. L.

PY - 2010/10

Y1 - 2010/10

N2 - The development of personality traits united by the notion of conscientiousness, should promote, along with reduction of anxiety, the physical and mental health. In order to detect the sources of conscientiousness and neurotism formation, we evaluated associations between polymorphic markers of 5-HTT, 5-HTR2A, and GABRA6 genes and relevant scores of TCI questionnaire in a group of 369 volunteers. Associations of markers VNTR and LPR of 5-HTT gene and marker T1521C of GABRA6 gene with "self-directedness" and the effects of 5-HTR2A gene marker T102C and its interactions with the GABRA6 gene on the "harm avoidance" were detected.

AB - The development of personality traits united by the notion of conscientiousness, should promote, along with reduction of anxiety, the physical and mental health. In order to detect the sources of conscientiousness and neurotism formation, we evaluated associations between polymorphic markers of 5-HTT, 5-HTR2A, and GABRA6 genes and relevant scores of TCI questionnaire in a group of 369 volunteers. Associations of markers VNTR and LPR of 5-HTT gene and marker T1521C of GABRA6 gene with "self-directedness" and the effects of 5-HTR2A gene marker T102C and its interactions with the GABRA6 gene on the "harm avoidance" were detected.

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KW - health

KW - personality

KW - serotonin

KW - γ-aminobutyric acid

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Analysis of associations between 5-HTT, 5-HTR2A, and GABRA6 gene polymorphisms and health-associated personality traits

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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