An integrated multi-omics analysis of sleep-disordered breathing traits implicates P2XR4 purinergic signaling

Nuzulul Kurniansyah; Danielle A. Wallace; Ying Zhang; Bing Yu; Brian Cade; Heming Wang; Heather M. Ochs-Balcom; Alexander P. Reiner; Alberto R. Ramos; Joshua D. Smith; Jianwen Cai; Martha Daviglus; Phyllis C. Zee; Robert Kaplan; Charles Kooperberg; Stephen S. Rich; Jerome I. Rotter; Sina A. Gharib; Susan Redline; Tamar Sofer

doi:10.1038/s42003-023-04520-y

An integrated multi-omics analysis of sleep-disordered breathing traits implicates P2XR4 purinergic signaling

Nuzulul Kurniansyah, Danielle A. Wallace, Ying Zhang, Bing Yu, Brian Cade, Heming Wang, Heather M. Ochs-Balcom, Alexander P. Reiner, Alberto R. Ramos, Joshua D. Smith, Jianwen Cai, Martha Daviglus, Phyllis C. Zee, Robert Kaplan, Charles Kooperberg, Stephen S. Rich, Jerome I. Rotter, Sina A. Gharib, Susan Redline, Tamar Sofer

Epidemiology & Population Health

Research output: Contribution to journal › Article › peer-review

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Abstract

Sleep Disordered Breathing (SDB) is a common disease associated with increased risk for cardiometabolic, cardiovascular, and cognitive diseases. How SDB affects the molecular environment is still poorly understood. We study the association of three SDB measures with gene expression measured using RNA-seq in multiple blood tissues from the Multi-Ethnic Study of Atherosclerosis. We develop genetic instrumental variables for the associated transcripts as polygenic risk scores (tPRS), then generalize and validate the tPRS in the Women’s Health Initiative. We measure the associations of the validated tPRS with SDB and serum metabolites in Hispanic Community Health Study/Study of Latinos. Here we find differential gene expression by blood cell type in relation to SDB traits and link P2XR4 expression to average oxyhemoglobin saturation during sleep and butyrylcarnitine (C4) levels. These findings can be used to develop interventions to alleviate the effect of SDB on the human molecular environment.

Original language	English (US)
Article number	125
Journal	Communications Biology
Volume	6
Issue number	1
DOIs	https://doi.org/10.1038/s42003-023-04520-y
State	Published - Dec 2023

ASJC Scopus subject areas

Medicine (miscellaneous)
General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s42003-023-04520-y

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Kurniansyah, N., Wallace, D. A., Zhang, Y., Yu, B., Cade, B., Wang, H., Ochs-Balcom, H. M., Reiner, A. P., Ramos, A. R., Smith, J. D., Cai, J., Daviglus, M., Zee, P. C., Kaplan, R., Kooperberg, C., Rich, S. S., Rotter, J. I., Gharib, S. A., Redline, S., & Sofer, T. (2023). An integrated multi-omics analysis of sleep-disordered breathing traits implicates P2XR4 purinergic signaling. Communications Biology, 6(1), Article 125. https://doi.org/10.1038/s42003-023-04520-y

Kurniansyah, N, Wallace, DA, Zhang, Y, Yu, B, Cade, B, Wang, H, Ochs-Balcom, HM, Reiner, AP, Ramos, AR, Smith, JD, Cai, J, Daviglus, M, Zee, PC, Kaplan, R, Kooperberg, C, Rich, SS, Rotter, JI, Gharib, SA, Redline, S & Sofer, T 2023, 'An integrated multi-omics analysis of sleep-disordered breathing traits implicates P2XR4 purinergic signaling', Communications Biology, vol. 6, no. 1, 125. https://doi.org/10.1038/s42003-023-04520-y

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abstract = "Sleep Disordered Breathing (SDB) is a common disease associated with increased risk for cardiometabolic, cardiovascular, and cognitive diseases. How SDB affects the molecular environment is still poorly understood. We study the association of three SDB measures with gene expression measured using RNA-seq in multiple blood tissues from the Multi-Ethnic Study of Atherosclerosis. We develop genetic instrumental variables for the associated transcripts as polygenic risk scores (tPRS), then generalize and validate the tPRS in the Women{\textquoteright}s Health Initiative. We measure the associations of the validated tPRS with SDB and serum metabolites in Hispanic Community Health Study/Study of Latinos. Here we find differential gene expression by blood cell type in relation to SDB traits and link P2XR4 expression to average oxyhemoglobin saturation during sleep and butyrylcarnitine (C4) levels. These findings can be used to develop interventions to alleviate the effect of SDB on the human molecular environment.",

author = "Nuzulul Kurniansyah and Wallace, {Danielle A.} and Ying Zhang and Bing Yu and Brian Cade and Heming Wang and Ochs-Balcom, {Heather M.} and Reiner, {Alexander P.} and Ramos, {Alberto R.} and Smith, {Joshua D.} and Jianwen Cai and Martha Daviglus and Zee, {Phyllis C.} and Robert Kaplan and Charles Kooperberg and Rich, {Stephen S.} and Rotter, {Jerome I.} and Gharib, {Sina A.} and Susan Redline and Tamar Sofer",

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doi = "10.1038/s42003-023-04520-y",

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AU - Kurniansyah, Nuzulul

AU - Wallace, Danielle A.

AU - Zhang, Ying

AU - Yu, Bing

AU - Cade, Brian

AU - Wang, Heming

AU - Ochs-Balcom, Heather M.

AU - Reiner, Alexander P.

AU - Ramos, Alberto R.

AU - Smith, Joshua D.

AU - Cai, Jianwen

AU - Daviglus, Martha

AU - Zee, Phyllis C.

AU - Kaplan, Robert

AU - Kooperberg, Charles

AU - Rich, Stephen S.

AU - Rotter, Jerome I.

AU - Gharib, Sina A.

AU - Redline, Susan

AU - Sofer, Tamar

PY - 2023/12

Y1 - 2023/12

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An integrated multi-omics analysis of sleep-disordered breathing traits implicates P2XR4 purinergic signaling

Abstract

ASJC Scopus subject areas

UN SDGs

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