An immunoperoxidase study on herpes simplex virus encephalitis

Toshiro Kumanishi, Asao Hirano

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Using formalin-fixed, paraffin-embedded sections, indirect immunoperoxidase studies were performed on 3 autopsied and 1 biopsied cases of herpes simplex virus (HSV) encephalitis. Specific reaction was observed in all 4 cases. Distinct stain was observed both in neurons and in glial cells. Electron microscopic studies performed on the same material revealed HSV particles stained with electron-dense reaction products. The advantages and disadvantages of the use of formalin-fixed, paraffin embedded material in immunoperoxidase studies of viral disease are discussed.

Original languageEnglish (US)
Pages (from-to)790-795
Number of pages6
JournalJournal of Neuropathology and Experimental Neurology
Issue number6
StatePublished - Nov 1978

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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