An emerging role for cytopathology in precision oncology

Chantal Pauli, Loredana Puca, Juan Miguel Mosquera, Brian D. Robinson, Himisha Beltran, Mark A. Rubin, Rema A. Rao

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Precision medicine is an emerging field in medicine for disease prevention and treatment that takes into account the individual variability in genes, environment, and lifestyle for each individual patient. The authors have developed a special program as part of the Englander Institute for Precision Medicine to grow patient-derived, 3-dimensional tumor organoids for tumor-specific drug testing, tailoring treatment strategies, and as models for studying drug resistance. Routine cytology preparations represent a cost-effective and powerful tool to aid in performing molecular testing in the age of personalized medicine. In this commentary, the platforms used for the characterization and validation of patient-derived, 3-dimensional tumor organoids are outlined and discussed, and the role of cytology as a cost-effective and powerful quality-control measure is illustrated.

Original languageEnglish (US)
Pages (from-to)167-173
Number of pages7
JournalCancer Cytopathology
Issue number3
StatePublished - Mar 1 2016
Externally publishedYes


  • 3-dimensional (3D) tumor organoid
  • cytology
  • cytology smear
  • in vitro models
  • next-generation sequencing
  • organoids
  • precision medicine

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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