Altered synaptophysin-immunoreactive pattern in human olivary hypertrophy

Toru Kawanami, Takeo Kato, Josephina F. Llena, Asao Hirano, Hideo Sasaki

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


We examined the inferior olivary nucleus from four cases of olivary hypertrophy and six control cases immunohistochemically with an anti-synaptophysin (SYP) antibody. Our study revealed the altered SYP-immunoreactive pattern in the hypertrophied olives, consisting of an increased number of SYP-immunoreactive dots on neuronal cell bodies in spite of its decreased immunoreactivity in the neuropil. Because SYP is a marker protein for presynaptic vesicles, presynaptic terminals in the inferior olivary nucleus seem to change their distribution during the course of olivary hypertrophy.

Original languageEnglish (US)
Pages (from-to)178-180
Number of pages3
JournalNeuroscience Letters
Issue number2
StatePublished - Aug 1 1994


  • Immunohistochemistry
  • Inferior olivary nucleus
  • Olivary hypertrophy
  • Presynaptic terminal
  • Synapse
  • Synaptic reorganization
  • Synaptophysin

ASJC Scopus subject areas

  • Neuroscience(all)


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