Altered synaptophysin-immunoreactive pattern in human olivary hypertrophy

Toru Kawanami; Takeo Kato; Josephina F. Llena; Asao Hirano; Hideo Sasaki

doi:10.1016/0304-3940(94)90076-0

Altered synaptophysin-immunoreactive pattern in human olivary hypertrophy

Toru Kawanami, Takeo Kato, Josephina F. Llena, Asao Hirano, Hideo Sasaki

Pathology

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

We examined the inferior olivary nucleus from four cases of olivary hypertrophy and six control cases immunohistochemically with an anti-synaptophysin (SYP) antibody. Our study revealed the altered SYP-immunoreactive pattern in the hypertrophied olives, consisting of an increased number of SYP-immunoreactive dots on neuronal cell bodies in spite of its decreased immunoreactivity in the neuropil. Because SYP is a marker protein for presynaptic vesicles, presynaptic terminals in the inferior olivary nucleus seem to change their distribution during the course of olivary hypertrophy.

Original language	English (US)
Pages (from-to)	178-180
Number of pages	3
Journal	Neuroscience Letters
Volume	176
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(94)90076-0
State	Published - Aug 1 1994

Keywords

Immunohistochemistry
Inferior olivary nucleus
Olivary hypertrophy
Presynaptic terminal
Synapse
Synaptic reorganization
Synaptophysin

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(94)90076-0

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title = "Altered synaptophysin-immunoreactive pattern in human olivary hypertrophy",

abstract = "We examined the inferior olivary nucleus from four cases of olivary hypertrophy and six control cases immunohistochemically with an anti-synaptophysin (SYP) antibody. Our study revealed the altered SYP-immunoreactive pattern in the hypertrophied olives, consisting of an increased number of SYP-immunoreactive dots on neuronal cell bodies in spite of its decreased immunoreactivity in the neuropil. Because SYP is a marker protein for presynaptic vesicles, presynaptic terminals in the inferior olivary nucleus seem to change their distribution during the course of olivary hypertrophy.",

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T1 - Altered synaptophysin-immunoreactive pattern in human olivary hypertrophy

AU - Kawanami, Toru

AU - Kato, Takeo

AU - Llena, Josephina F.

AU - Hirano, Asao

AU - Sasaki, Hideo

PY - 1994/8/1

Y1 - 1994/8/1

N2 - We examined the inferior olivary nucleus from four cases of olivary hypertrophy and six control cases immunohistochemically with an anti-synaptophysin (SYP) antibody. Our study revealed the altered SYP-immunoreactive pattern in the hypertrophied olives, consisting of an increased number of SYP-immunoreactive dots on neuronal cell bodies in spite of its decreased immunoreactivity in the neuropil. Because SYP is a marker protein for presynaptic vesicles, presynaptic terminals in the inferior olivary nucleus seem to change their distribution during the course of olivary hypertrophy.

AB - We examined the inferior olivary nucleus from four cases of olivary hypertrophy and six control cases immunohistochemically with an anti-synaptophysin (SYP) antibody. Our study revealed the altered SYP-immunoreactive pattern in the hypertrophied olives, consisting of an increased number of SYP-immunoreactive dots on neuronal cell bodies in spite of its decreased immunoreactivity in the neuropil. Because SYP is a marker protein for presynaptic vesicles, presynaptic terminals in the inferior olivary nucleus seem to change their distribution during the course of olivary hypertrophy.

KW - Immunohistochemistry

KW - Inferior olivary nucleus

KW - Olivary hypertrophy

KW - Presynaptic terminal

KW - Synapse

KW - Synaptic reorganization

KW - Synaptophysin

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Altered synaptophysin-immunoreactive pattern in human olivary hypertrophy

Abstract

Keywords

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