TY - JOUR
T1 - Altered cortical structure network in children with obstructive sleep apnea
AU - Lee, Min Hee
AU - Sin, Sanghun
AU - Lee, Seonjoo
AU - Park, Hyunbin
AU - Wagshul, Mark E.
AU - Zimmerman, Molly E.
AU - Arens, Raanan
N1 - Publisher Copyright:
© 2022 The Author(s) 2022. Published by Oxford University Press on behalf of Sleep Research Society. All rights reserved. For permissions, please e-mail: [email protected].
PY - 2022/5/1
Y1 - 2022/5/1
N2 - Study Objectives: Obstructive sleep apnea (OSA) is characterized by recurrent airway collapse during sleep, resulting in intermittent hypoxia and sleep fragmentation that may contribute to alternations in brain structure and function. We hypothesized that OSA in children reorganizes and alters cortical structure, which can cause changes in cortical thickness correlation between brain regions across subjects. Methods: We constructed cortical structure networks based on cortical thickness measurements from 41 controls (age 15.54±1.66 years, male 19) and 50 children with OSA (age 15.32±1.65 years, male 29). The global (clustering coefficient [CC], path length, and small-worldness) and regional (nodal betweenness centrality, NBC) network properties and hub region distributions were examined between groups. Results: We found increased CCs in OSA compared to controls across a wide range of network densities (p-value<.05) and lower NBC area under the curve in left caudal anterior cingulate, left caudal middle frontal, left fusiform, left transverse temporal, right pars opercularis, and right precentral gyri (p-value<.05). In addition, while most of the hub regions were the same between groups, the OSA group had fewer hub regions and a different hub distribution compared to controls. Conclusions: Our findings suggest that children with OSA exhibit altered global and regional network characteristics compared to healthy controls. Our approach to the investigation of cortical structure in children with OSA could prove useful in understanding the etiology of OSA-related brain functional disorders.
AB - Study Objectives: Obstructive sleep apnea (OSA) is characterized by recurrent airway collapse during sleep, resulting in intermittent hypoxia and sleep fragmentation that may contribute to alternations in brain structure and function. We hypothesized that OSA in children reorganizes and alters cortical structure, which can cause changes in cortical thickness correlation between brain regions across subjects. Methods: We constructed cortical structure networks based on cortical thickness measurements from 41 controls (age 15.54±1.66 years, male 19) and 50 children with OSA (age 15.32±1.65 years, male 29). The global (clustering coefficient [CC], path length, and small-worldness) and regional (nodal betweenness centrality, NBC) network properties and hub region distributions were examined between groups. Results: We found increased CCs in OSA compared to controls across a wide range of network densities (p-value<.05) and lower NBC area under the curve in left caudal anterior cingulate, left caudal middle frontal, left fusiform, left transverse temporal, right pars opercularis, and right precentral gyri (p-value<.05). In addition, while most of the hub regions were the same between groups, the OSA group had fewer hub regions and a different hub distribution compared to controls. Conclusions: Our findings suggest that children with OSA exhibit altered global and regional network characteristics compared to healthy controls. Our approach to the investigation of cortical structure in children with OSA could prove useful in understanding the etiology of OSA-related brain functional disorders.
KW - T1-weighted imaging
KW - children with obstructive sleep apnea
KW - cortical structure network
KW - cortical thickness
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U2 - 10.1093/sleep/zsac030
DO - 10.1093/sleep/zsac030
M3 - Article
C2 - 35554588
AN - SCOPUS:85130019400
SN - 0161-8105
VL - 45
JO - Sleep
JF - Sleep
IS - 5
M1 - zsac030
ER -