Albright's hereditary osteodystrophy and defective g proteins

Research output: Contribution to journalEditorialpeer-review

31 Scopus citations


Given the myriad extracellular signals impinging on cells, the number of mechanisms used to convey information to them is surprisingly limited. A common feature is a signal discriminator, better known as a receptor. Often, the receptor is also an intracellular signal generator. Binding of an activating signal to the receptor triggers its intrinsic signal-generating capacity. An exception to this pattern is a large class of cell-surface receptors that are coupled to distinct intracellular signal generators by molecular go-betweens, called G proteins. G proteins are products of a large gene family. They specifically bind guanine nucleotides and hydrolyze the last phosphate.

Original languageEnglish (US)
Pages (from-to)1461-1462
Number of pages2
JournalNew England Journal of Medicine
Issue number20
StatePublished - May 17 1990
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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