Aging: A Sirtuin Shake-Up?

Jan Vijg; Alexander Y. Maslov; Yousin Suh

doi:10.1016/j.cell.2008.11.008

Aging: A Sirtuin Shake-Up?

Jan Vijg, Alexander Y. Maslov, Yousin Suh

Genetics

Research output: Contribution to journal › Short survey › peer-review

18 Scopus citations

Abstract

The yeast sirtuin (Sir2) is a histone deacetylase that modulates yeast replicative life span by suppressing genome instability through chromatin modification. In this issue, Oberdoerffer et al. (2008) report that SIRT1, the mammalian ortholog of Sir2, is involved in DNA damage-induced chromatin reorganization, which promotes genome stability in mammalian cells.

Original language	English (US)
Pages (from-to)	797-798
Number of pages	2
Journal	Cell
Volume	135
Issue number	5
DOIs	https://doi.org/10.1016/j.cell.2008.11.008
State	Published - Nov 28 2008

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.cell.2008.11.008

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title = "Aging: A Sirtuin Shake-Up?",

abstract = "The yeast sirtuin (Sir2) is a histone deacetylase that modulates yeast replicative life span by suppressing genome instability through chromatin modification. In this issue, Oberdoerffer et al. (2008) report that SIRT1, the mammalian ortholog of Sir2, is involved in DNA damage-induced chromatin reorganization, which promotes genome stability in mammalian cells.",

author = "Jan Vijg and Maslov, {Alexander Y.} and Yousin Suh",

year = "2008",

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TY - JOUR

T1 - Aging

T2 - A Sirtuin Shake-Up?

AU - Vijg, Jan

AU - Maslov, Alexander Y.

AU - Suh, Yousin

PY - 2008/11/28

Y1 - 2008/11/28

N2 - The yeast sirtuin (Sir2) is a histone deacetylase that modulates yeast replicative life span by suppressing genome instability through chromatin modification. In this issue, Oberdoerffer et al. (2008) report that SIRT1, the mammalian ortholog of Sir2, is involved in DNA damage-induced chromatin reorganization, which promotes genome stability in mammalian cells.

AB - The yeast sirtuin (Sir2) is a histone deacetylase that modulates yeast replicative life span by suppressing genome instability through chromatin modification. In this issue, Oberdoerffer et al. (2008) report that SIRT1, the mammalian ortholog of Sir2, is involved in DNA damage-induced chromatin reorganization, which promotes genome stability in mammalian cells.

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DO - 10.1016/j.cell.2008.11.008

M3 - Short survey

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SN - 0092-8674

VL - 135

SP - 797

EP - 798

JO - Cell

JF - Cell

IS - 5

ER -

Aging: A Sirtuin Shake-Up?

Abstract

ASJC Scopus subject areas

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