Aging: A Sirtuin Shake-Up?

Research output: Contribution to journalShort surveypeer-review

18 Scopus citations


The yeast sirtuin (Sir2) is a histone deacetylase that modulates yeast replicative life span by suppressing genome instability through chromatin modification. In this issue, Oberdoerffer et al. (2008) report that SIRT1, the mammalian ortholog of Sir2, is involved in DNA damage-induced chromatin reorganization, which promotes genome stability in mammalian cells.

Original languageEnglish (US)
Pages (from-to)797-798
Number of pages2
Issue number5
StatePublished - Nov 28 2008

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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