Aggressive squamous cell carcinoma of the skin after chronic lymphocytic leukemia

Nancy Bridges, J. J. Steinberg

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


We report two cases of squamous cell carcinoma (SCC) of the skin subsequent to chronic lymphocytic leukemia (CLL). Both cases had an unusually aggressive course for a nonmelanoma skin malignancy with extensive metastases in both, resulting in death in one patient. A literature review supports the likelihood of an increased incidence of SCC in patients with CLL. Though the mechanism is unknown, immunosuppression may play a central role. We urge patients with CLL to avoid exposure to direct sun. Any questionable skin lesion should be biopsied early, and completely excised if it is a tumor. The patient should also be examined thoroughly for metastatic disease via subsequent follow‐up visits.

Original languageEnglish (US)
Pages (from-to)27-30
Number of pages4
JournalJournal of Surgical Oncology
Issue number1
StatePublished - Sep 1986


  • chemotherapy
  • chronic lymphocytic leukemia
  • radiation
  • second primary
  • squamous cell carcinoma of skin
  • ultra‐violet

ASJC Scopus subject areas

  • Surgery
  • Oncology


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