TY - JOUR
T1 - Age‐Related Differences in the Effects of GABA, Agonists Microinjected Into Rat Substantia Nigra
T2 - Pro‐ and Anticonvulsant Actions
AU - Garant, D. S.
AU - Xu, S. G.
AU - Sperber, E. F.
AU - Moshé, S. L.
PY - 1995/10
Y1 - 1995/10
N2 - Summary: GABAergic transmission in the substantia nigra pars reticulata (SNR) has an important role in the control of experimental seizures. In the flurothyl seizure model, SNR microinjection of the selective GABA, receptor agonist muscimol results in a biphasic dose‐response curve in adults: Intermediate doses are anticonvulsant, but high doses have proconvulsant effects. Another GABAA agonist, THIP (4,5,6,7‐tetrahydroisox‐azolo‐[5,4‐c]pyndin‐3‐01), also produces anticonvulsant effects at lower doses, whereas higher doses tend to produce a proconvulsant effect. In 16‐day‐old rat pups, no Both clinically and experimentally, it is recognized that the immature brain is at increased risk for sustaining epileptic seizures, particularly generalized seizures (1). An important goal of neuroscience research is to identify the neuronal circuitry and synaptic pharmacology underlying this ontogenic phenomenon. Such understanding will help direct the development of more efficacious and selective age‐specific therapies than those currently available.
AB - Summary: GABAergic transmission in the substantia nigra pars reticulata (SNR) has an important role in the control of experimental seizures. In the flurothyl seizure model, SNR microinjection of the selective GABA, receptor agonist muscimol results in a biphasic dose‐response curve in adults: Intermediate doses are anticonvulsant, but high doses have proconvulsant effects. Another GABAA agonist, THIP (4,5,6,7‐tetrahydroisox‐azolo‐[5,4‐c]pyndin‐3‐01), also produces anticonvulsant effects at lower doses, whereas higher doses tend to produce a proconvulsant effect. In 16‐day‐old rat pups, no Both clinically and experimentally, it is recognized that the immature brain is at increased risk for sustaining epileptic seizures, particularly generalized seizures (1). An important goal of neuroscience research is to identify the neuronal circuitry and synaptic pharmacology underlying this ontogenic phenomenon. Such understanding will help direct the development of more efficacious and selective age‐specific therapies than those currently available.
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U2 - 10.1111/j.1528-1157.1995.tb00953.x
DO - 10.1111/j.1528-1157.1995.tb00953.x
M3 - Article
C2 - 7555959
AN - SCOPUS:0029084826
SN - 0013-9580
VL - 36
SP - 960
EP - 965
JO - Epilepsia
JF - Epilepsia
IS - 10
ER -