Age‐Dependent Differences in the Anticonvulsant Effects of 2–Amino‐7‐Phosphono‐Heptanoic Acid or Ketamine Infusions Into the Substantia Nigra of Rats

John N.D. Wurpel; Ellen F. Sperber; Solomon L. Moshé

doi:10.1111/j.1528-1157.1992.tb01688.x

Age‐Dependent Differences in the Anticonvulsant Effects of 2–Amino‐7‐Phosphono‐Heptanoic Acid or Ketamine Infusions Into the Substantia Nigra of Rats

John N.D. Wurpel, Ellen F. Sperber, Solomon L. Moshé

Neurology

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Summary: Infusions of 2‐amino‐7‐phosphonoheptanoic acid (AP7) or ketamine into the substantia nigra pars reticulata (SNPR) of adult rats increase the latency of onset to seizures induced by the convulsant ether flurothyl. Nigral infusions of AP7 or ketamine in concentrations up to 10 times greater than the adult dose are ineffective in 16‐day‐old rats. These results suggest that differences in seizure susceptibility between adult and immature rats may be related to differences in excitatory amino acid neurotransmission in the SN.

Original language	English (US)
Pages (from-to)	439-443
Number of pages	5
Journal	Epilepsia
Volume	33
Issue number	3
DOIs	https://doi.org/10.1111/j.1528-1157.1992.tb01688.x
State	Published - May 1992

Keywords

2‐Amino‐7‐phospho‐hepatanoic acid
Convulsions
Ketamine
Neurologic model
Substantia nigra

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1111/j.1528-1157.1992.tb01688.x

Cite this

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abstract = "Summary: Infusions of 2‐amino‐7‐phosphonoheptanoic acid (AP7) or ketamine into the substantia nigra pars reticulata (SNPR) of adult rats increase the latency of onset to seizures induced by the convulsant ether flurothyl. Nigral infusions of AP7 or ketamine in concentrations up to 10 times greater than the adult dose are ineffective in 16‐day‐old rats. These results suggest that differences in seizure susceptibility between adult and immature rats may be related to differences in excitatory amino acid neurotransmission in the SN.",

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AB - Summary: Infusions of 2‐amino‐7‐phosphonoheptanoic acid (AP7) or ketamine into the substantia nigra pars reticulata (SNPR) of adult rats increase the latency of onset to seizures induced by the convulsant ether flurothyl. Nigral infusions of AP7 or ketamine in concentrations up to 10 times greater than the adult dose are ineffective in 16‐day‐old rats. These results suggest that differences in seizure susceptibility between adult and immature rats may be related to differences in excitatory amino acid neurotransmission in the SN.

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Age‐Dependent Differences in the Anticonvulsant Effects of 2–Amino‐7‐Phosphono‐Heptanoic Acid or Ketamine Infusions Into the Substantia Nigra of Rats

Abstract

Keywords

ASJC Scopus subject areas

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