TY - JOUR
T1 - Age-specific and sex-specific prevalence and incidence of mild cognitive impairment, dementia, and alzheimer dementia in blacks and whites
T2 - A report from the Einstein aging study
AU - Katz, Mindy J.
AU - Lipton, Richard B.
AU - Hall, Charles B.
AU - Zimmerman, Molly E.
AU - Sanders, Amy E.
AU - Verghese, Joe
AU - Dickson, Dennis W.
AU - Derby, Carol A.
PY - 2012/10
Y1 - 2012/10
N2 - As the population ages, the need to characterize rates of cognitive impairment and dementia within demographic groups defined by age, sex, and race becomes increasingly important. There are limited data available on the prevalence and incidence of amnestic mild cognitive impairment (aMCI) and nonamnestic mild cognitive impairment (naMCI) from population-based studies. The Einstein Aging Study, a systematically recruited community-based cohort of 1944 adults aged 70 or older (1168 dementia free at baseline; mean age, 78.8 y; average follow-up, 3.9 y), provides the opportunity to examine the prevalence and incidence rates for dementia, Alzheimer dementia (AD), aMCI, and naMCI by demographic characteristics. Dementia prevalence was 6.5% (4.9% AD). Overall dementia incidence was 2.9/100 person-years (2.3/100 person-years for AD). Dementia and AD rates increased with age but did not differ by sex. Prevalence of aMCI was 11.6%, and naMCI prevalence was 9.9%. aMCI incidence was 3.8 and naMCI incidence was 3.9/100 person-years. Rates of aMCI increased significantly with age in men and in blacks; sex, education, and race were not significant risk factors. In contrast, naMCI incidence did not increase with age; however, blacks were at higher risk compared with whites, even when controlling for sex and education. Results highlight the public health significance of preclinical cognitive disease.
AB - As the population ages, the need to characterize rates of cognitive impairment and dementia within demographic groups defined by age, sex, and race becomes increasingly important. There are limited data available on the prevalence and incidence of amnestic mild cognitive impairment (aMCI) and nonamnestic mild cognitive impairment (naMCI) from population-based studies. The Einstein Aging Study, a systematically recruited community-based cohort of 1944 adults aged 70 or older (1168 dementia free at baseline; mean age, 78.8 y; average follow-up, 3.9 y), provides the opportunity to examine the prevalence and incidence rates for dementia, Alzheimer dementia (AD), aMCI, and naMCI by demographic characteristics. Dementia prevalence was 6.5% (4.9% AD). Overall dementia incidence was 2.9/100 person-years (2.3/100 person-years for AD). Dementia and AD rates increased with age but did not differ by sex. Prevalence of aMCI was 11.6%, and naMCI prevalence was 9.9%. aMCI incidence was 3.8 and naMCI incidence was 3.9/100 person-years. Rates of aMCI increased significantly with age in men and in blacks; sex, education, and race were not significant risk factors. In contrast, naMCI incidence did not increase with age; however, blacks were at higher risk compared with whites, even when controlling for sex and education. Results highlight the public health significance of preclinical cognitive disease.
KW - Alzheimer dementia
KW - amnestic mild cognitive impairment
KW - cohort study
KW - dementia
KW - nonamnestic mild cognitive impairment
UR - http://www.scopus.com/inward/record.url?scp=84870247069&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84870247069&partnerID=8YFLogxK
U2 - 10.1097/WAD.0b013e31823dbcfc
DO - 10.1097/WAD.0b013e31823dbcfc
M3 - Article
C2 - 22156756
AN - SCOPUS:84870247069
SN - 0893-0341
VL - 26
SP - 335
EP - 343
JO - Alzheimer Disease and Associated Disorders
JF - Alzheimer Disease and Associated Disorders
IS - 4
ER -