Age-related differences in seizure susceptibility to flurothyl

Ellen F. Sperber; Solomon L. Moshé

doi:10.1016/0165-3806(88)90033-8

Age-related differences in seizure susceptibility to flurothyl

Ellen F. Sperber, Solomon L. Moshé

Neurology

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

The purpose of the present study was to determine whether the susceptibility to seizures induced by inhalation of flurothyl ether (FE) varies with age. Adult rats and 16-day-old rat pups were tested in different sized chambers to also determine whether the size of the FE-test chamber influences seizure thresholds. Results indicate that pups developed age-specific seizure patterns; their seizure latency thresholds were shorter than those of adult animals. For both age-groups, seizure thresholds varied as a function of chamber size; the smaller the chamber the faster seizures occurred.

Original language	English (US)
Pages (from-to)	295-297
Number of pages	3
Journal	Developmental Brain Research
Volume	39
Issue number	2
DOIs	https://doi.org/10.1016/0165-3806(88)90033-8
State	Published - Apr 1 1988

Keywords

Animal newborn
Convulsion
Flurothyl
Rat
Seizure

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

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10.1016/0165-3806(88)90033-8

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title = "Age-related differences in seizure susceptibility to flurothyl",

abstract = "The purpose of the present study was to determine whether the susceptibility to seizures induced by inhalation of flurothyl ether (FE) varies with age. Adult rats and 16-day-old rat pups were tested in different sized chambers to also determine whether the size of the FE-test chamber influences seizure thresholds. Results indicate that pups developed age-specific seizure patterns; their seizure latency thresholds were shorter than those of adult animals. For both age-groups, seizure thresholds varied as a function of chamber size; the smaller the chamber the faster seizures occurred.",

keywords = "Animal newborn, Convulsion, Flurothyl, Rat, Seizure",

author = "Sperber, {Ellen F.} and Mosh{\'e}, {Solomon L.}",

note = "Funding Information: Supported by NIH Grant NS-20253 from the NINCDS and R-36986 from the United Cerebral Palsy Associations. The authors thank Ms. Donna Platy-an for her secretarial assistance.",

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AU - Moshé, Solomon L.

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N2 - The purpose of the present study was to determine whether the susceptibility to seizures induced by inhalation of flurothyl ether (FE) varies with age. Adult rats and 16-day-old rat pups were tested in different sized chambers to also determine whether the size of the FE-test chamber influences seizure thresholds. Results indicate that pups developed age-specific seizure patterns; their seizure latency thresholds were shorter than those of adult animals. For both age-groups, seizure thresholds varied as a function of chamber size; the smaller the chamber the faster seizures occurred.

AB - The purpose of the present study was to determine whether the susceptibility to seizures induced by inhalation of flurothyl ether (FE) varies with age. Adult rats and 16-day-old rat pups were tested in different sized chambers to also determine whether the size of the FE-test chamber influences seizure thresholds. Results indicate that pups developed age-specific seizure patterns; their seizure latency thresholds were shorter than those of adult animals. For both age-groups, seizure thresholds varied as a function of chamber size; the smaller the chamber the faster seizures occurred.

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KW - Convulsion

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KW - Seizure

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Age-related differences in seizure susceptibility to flurothyl

Abstract

Keywords

ASJC Scopus subject areas

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