Age-related changes of muscimol binding in the substantia nigra

John N.D. Wurpel; Ann Tempel; Ellen F. Sperber; Solomon L. Moshé

doi:10.1016/0165-3806(88)90108-3

Age-related changes of muscimol binding in the substantia nigra

John N.D. Wurpel, Ann Tempel, Ellen F. Sperber, Solomon L. Moshé

Neurology

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Receptor binding studies of the substantia nigra (SN) and cerebellum revealed two affinity sites for muscimol binding in the SN and cerebellum of adult and 16-day-old rats. Scatchard analysis revealed a paucity of high-affinity muscimol receptors in the SN of 16-day-old rat pups. These results suggest that the lack of anticonvulsant action of muscimol in the SN of 16-day-old rat pups may be due to the paucity of high-affinity muscimol receptors as compared to adult rats.

Original language	English (US)
Pages (from-to)	305-308
Number of pages	4
Journal	Developmental Brain Research
Volume	43
Issue number	2
DOIs	https://doi.org/10.1016/0165-3806(88)90108-3
State	Published - Oct 1 1988

Keywords

Animal, newborn
Muscimol
Rat
Substantia nigra
γ-Aminobutyric acid receptor

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

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10.1016/0165-3806(88)90108-3

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title = "Age-related changes of muscimol binding in the substantia nigra",

abstract = "Receptor binding studies of the substantia nigra (SN) and cerebellum revealed two affinity sites for muscimol binding in the SN and cerebellum of adult and 16-day-old rats. Scatchard analysis revealed a paucity of high-affinity muscimol receptors in the SN of 16-day-old rat pups. These results suggest that the lack of anticonvulsant action of muscimol in the SN of 16-day-old rat pups may be due to the paucity of high-affinity muscimol receptors as compared to adult rats.",

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note = "Funding Information: The authors wish to acknowledge Diane M. Olive for her excellent technical assistance. These experiments were supported by the following grants; NIDA, DA-04439; Training Grant 5-T32, MH 15788; NIH, NS-21973 (A.T.); NINCDS, NS-20253 (S.L.M.).",

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AU - Tempel, Ann

AU - Sperber, Ellen F.

AU - Moshé, Solomon L.

N1 - Funding Information: The authors wish to acknowledge Diane M. Olive for her excellent technical assistance. These experiments were supported by the following grants; NIDA, DA-04439; Training Grant 5-T32, MH 15788; NIH, NS-21973 (A.T.); NINCDS, NS-20253 (S.L.M.).

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N2 - Receptor binding studies of the substantia nigra (SN) and cerebellum revealed two affinity sites for muscimol binding in the SN and cerebellum of adult and 16-day-old rats. Scatchard analysis revealed a paucity of high-affinity muscimol receptors in the SN of 16-day-old rat pups. These results suggest that the lack of anticonvulsant action of muscimol in the SN of 16-day-old rat pups may be due to the paucity of high-affinity muscimol receptors as compared to adult rats.

AB - Receptor binding studies of the substantia nigra (SN) and cerebellum revealed two affinity sites for muscimol binding in the SN and cerebellum of adult and 16-day-old rats. Scatchard analysis revealed a paucity of high-affinity muscimol receptors in the SN of 16-day-old rat pups. These results suggest that the lack of anticonvulsant action of muscimol in the SN of 16-day-old rat pups may be due to the paucity of high-affinity muscimol receptors as compared to adult rats.

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KW - Rat

KW - Substantia nigra

KW - γ-Aminobutyric acid receptor

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Age-related changes of muscimol binding in the substantia nigra

Abstract

Keywords

ASJC Scopus subject areas

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