TY - JOUR
T1 - Adrenoleukodystrophy
T2 - A Clinical and Pathological Study of 17 Cases
AU - Schaumburg, Herbert H.
AU - Powers, James M.
AU - Raine, Cedric S.
AU - Suzuki, Kinuko
AU - Richardson, Edward P.
PY - 1975/9
Y1 - 1975/9
N2 - Adrenoleukodystrophy was diagnosed pathologically in 17 male patients. The diagnosis was suggested by clinical and laboratory signs of primary adrenal failure and by neurological signs referable to the degeneration of white matter. Neurological findings usually predominated over clinical stigmata of adrenal failure. Adrenal biopsy has proved to be the most reliable diagnostic test, while brain biopsy has often been misleading. The histological picture of the brain lesion differs substantially from that of the adrenal, but the presence of similar ultrastructural cytoplasmic inclusions suggests a common metabolic disorder. Morphological analysis of the cerebral lesion indicates that the destruction may spread in a caudal-rostral direction. The intense inflammatory cell response occurs within the demyelinated areas, behind the area of active myelin breakdown, and appears to be a secondary feature of white matter degeneration.
AB - Adrenoleukodystrophy was diagnosed pathologically in 17 male patients. The diagnosis was suggested by clinical and laboratory signs of primary adrenal failure and by neurological signs referable to the degeneration of white matter. Neurological findings usually predominated over clinical stigmata of adrenal failure. Adrenal biopsy has proved to be the most reliable diagnostic test, while brain biopsy has often been misleading. The histological picture of the brain lesion differs substantially from that of the adrenal, but the presence of similar ultrastructural cytoplasmic inclusions suggests a common metabolic disorder. Morphological analysis of the cerebral lesion indicates that the destruction may spread in a caudal-rostral direction. The intense inflammatory cell response occurs within the demyelinated areas, behind the area of active myelin breakdown, and appears to be a secondary feature of white matter degeneration.
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U2 - 10.1001/archneur.1975.00490510033001
DO - 10.1001/archneur.1975.00490510033001
M3 - Article
C2 - 169765
AN - SCOPUS:0016829831
SN - 0003-9942
VL - 32
SP - 577
EP - 591
JO - Archives of Neurology
JF - Archives of Neurology
IS - 9
ER -