TY - JOUR
T1 - Adjunctive immune therapy for fungal infections
AU - Casadevall, A.
AU - Pirofski, L. A.
N1 - Funding Information:
Financial support: National Institutes of Health (NIH) awards AI33774, AI3342, and HL-59842-01 (A.C.); Burroughs Wellcome Development Therapeutics Award (A.C.); NIH grants AI 35370 and 45459 (L.P.).
PY - 2001/10/1
Y1 - 2001/10/1
N2 - Fungal infections in immunocompromised patients can pose difficult problems in clinical management, because the available antifungal chemotherapy is often unable to eradicate the infection in these people. Hence, the use of immune modulating therapy to augment impaired host immune responses - and thus enhance the efficacy of antifungal drugs - is a reasonable approach to improve the prognosis of fungal infections. Advances in biotechnology have produced a variety of biological response modifiers with the potential to serve as adjunctive immune therapy for the treatment of fungal infections, including cytokines, monoclonal antibodies, and cell growth factors. In recent years, immune-modulating therapies have been studied in an effort to define their potential use for the treatment of fungal infections. Much of the available information on the use of this approach is encouraging and invites further investigation - with the caveats that the information is mostly anecdotal and that immune-modulating therapy occasionally has produced adverse effects.
AB - Fungal infections in immunocompromised patients can pose difficult problems in clinical management, because the available antifungal chemotherapy is often unable to eradicate the infection in these people. Hence, the use of immune modulating therapy to augment impaired host immune responses - and thus enhance the efficacy of antifungal drugs - is a reasonable approach to improve the prognosis of fungal infections. Advances in biotechnology have produced a variety of biological response modifiers with the potential to serve as adjunctive immune therapy for the treatment of fungal infections, including cytokines, monoclonal antibodies, and cell growth factors. In recent years, immune-modulating therapies have been studied in an effort to define their potential use for the treatment of fungal infections. Much of the available information on the use of this approach is encouraging and invites further investigation - with the caveats that the information is mostly anecdotal and that immune-modulating therapy occasionally has produced adverse effects.
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U2 - 10.1086/322710
DO - 10.1086/322710
M3 - Review article
C2 - 11528579
AN - SCOPUS:0035478082
SN - 1058-4838
VL - 33
SP - 1048
EP - 1056
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 7
ER -